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Molecular Detection of Antibiotic Resistance and H Pylori Eradication

NCT01168063 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1386

Last updated 2013-11-08

No results posted yet for this study

Summary

H pylori eradication failure with recommended triple therapy is mainly related to antibiotic resistance. However,IN VITRO culture of H pylori is uneasy and is not performed in routine practice. A molecular test of antibiotic resistance easy to perform is now available. The aim of the study was to compare eradication rates obtained with the standard treatment and with a treatment guided by the results of the molecular detection of antibiotic resistance.

Conditions

  • Helicobacter Pylori Infection

Interventions

DRUG

Molecular detection of antibiotic resistance

Helico DR®, triple therapy (Proton Pomp Inhibitor (PPI), amoxicillin, clarithromycin, metronidazole)

DRUG

standard triple therapy (PPI, amoxicillin, clarithromycin, metronidazole)

2 lines of treatments : 1\) PPI + Amoxicillin + Clarithromycin for 7 days 1\) PPI + Amoxicillin + Metronidazole for 14 days

Sponsors & Collaborators

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Jean-Charles Delchier, PU-PH · Assistance Publique - Hôpitaux de Paris

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2012-03-31
Completion
2013-03-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01168063 on ClinicalTrials.gov