MedTrace Logo

Allogeneic Vascularized Knee Transplantation

NCT01133145 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2010-05-28

No results posted yet for this study

Summary

High energy trauma often results in severe soft tissue, bone and joint injury. Today, many methods and techniques exist to treat theses severely injured extremities. Surgical techniques include open reduction and internal fixation (ORIF), e.g. with screws and plates, soft tissue reconstruction by local or free flaps and joint reconstruction by arthroplasty, e.g. total knee arthroplasty. In few, very severe cases, those methods are not sufficient to restore function and amputation is the only option left.

In 1908 the German surgeon Erich Lexer had the idea to transplant a joint. Due to the medical situation at his time the attempts failed.

But the idea survived and was processed over the time. Transplant surgery and medicine developed, immunosuppressive drugs were established and animal models proved that bone and joint transplantation is technically feasible.

In 1998 the first successful hand and in 2005 the first partial face transplantation was carried out. In 1996 we started our clinical femur and knee joint transplantation project.

Conditions

  • Osteitis
  • Limb Salvage
  • Joint Deformities, Acquired
  • Skin Transplantation
  • Bone Transplantation

Interventions

PROCEDURE

knee joint transplantation

transplantation of a kne joint from a multi organ donor to a recipient with a severly injured knee joint

Sponsors & Collaborators

  • University of Jena

    lead OTHER

Principal Investigators

  • Gunther O Hofmann, Prof. Dr. · Clinic of Trauma-, Hand, and Reconstructive Surgery, University of jena

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Primary Completion
2011-12-31
Completion
2012-06-30

Countries

  • Germany

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01133145 on ClinicalTrials.gov