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The Effect of High PCO2 Solution on Esophageal Acid Sensation

NCT01128608 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2010-07-21

No results posted yet for this study

Summary

To determine the effect of intraesophageal high PCO2 solution as compared to acidic and saline solutions on subjects' heartburn sensation using stiumlus-response functions.

Conditions

  • Gastroesophageal Reflux Disease

Interventions

PROCEDURE

24-Hr Esohpageal pH Monitoring

There will be a 24-hr pH monitoring procedure and two 10-minute infusions each one week apart consisting of high PCO2 solution and 0.1 N HCI solution.

PROCEDURE

PCO2 Acid Perfusion and 0.1N HCI Perfusion

A small tube will be inserted through the nostril and into the esophagus. A mild CO2 solution or a mild saline solution will be administered for aprox. 10 minutes during which you will be asked questions regarding any symptoms you may experience.

Sponsors & Collaborators

  • Southern Arizona VA Health Care System

    lead FED

Principal Investigators

  • Ronnie Fass, MD · Southern Arizona Veterans Health Care System

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-09-30
Primary Completion
2010-10-31
Completion
2010-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01128608 on ClinicalTrials.gov