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Vaccine Hyporesponse in Healthy Elderly Participants (MK-0000-131 AM2)

NCT01119703 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 174

Last updated 2015-12-29

Study results available
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Summary

This study evaluated whether it is possible in healthy elderly participants to generate baseline biomarker-based prediction rules (PdR) for vaccine response (post baseline absolute serum antibody titer) using each of the protocol selected vaccines separately; and examined the rank correlation coefficients of pairs of post vaccination antibody titers within the same elderly individuals.

Conditions

  • Vaccine Response Impaired

Interventions

BIOLOGICAL

Tetanus & Diphtheria booster vaccine (Td)

Tetanus \& Diphtheria booster vaccine (Td), single intramuscular dose

BIOLOGICAL

TwinrixTM [Hepatitis A Inactivated & Hepatitis B (Recombinant) Vaccine]

TwinrixTM \[Hepatitis A Inactivated \& Hepatitis B (Recombinant) Vaccine\], intramuscular, two doses of standard three dose regimen (opposite arms)

BIOLOGICAL

Dukoral® Traveler's Diarrhea Vaccine (WC/rBS)

Dukoral® Traveler's Diarrhea Vaccine, recombinant Cholera toxin B subunit (WC/rBS), standard two oral doses per treatment regimen

Sponsors & Collaborators

Principal Investigators

  • Francois St-Maurice, MD · Anapharm

  • Denis Audet, MD · Anapharm

Eligibility

Min Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-07-31
Primary Completion
2011-11-30
Completion
2011-11-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01119703 on ClinicalTrials.gov