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Effect of Daily Nicotine Patch Application on Mechanical Ventilation Weaning in Smoking Patients

NCT01104896 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2010-04-16

No results posted yet for this study

Summary

Nicotine patches are frequently used in smoking patients during their stay in the ICU in order to avoid tobacco's weaning symptoms which are likely to interfere with mechanical ventilation weaning.

Until now the effectiveness of this treatment has not been proven. The aim of this study (NICOREA study) is to determine if a difference exists on the duration of mechanical ventilation once patients receive or not a nicotine substitute.

Conditions

  • Smoking
  • Mechanical Ventilation
  • Intensive Care

Interventions

DRUG

Nicotine patch

One or two 15 mg nicotine patch(es) applied from 6am to 10 pm during 21 days

DRUG

Placebo

One or two placebo patch(es) applied from 6am to 10 pm each day for 21 days

Sponsors & Collaborators

  • Assistance Publique - Hôpitaux de Paris

    collaborator OTHER

  • University of Paris 5 - Rene Descartes

    lead OTHER

Principal Investigators

  • Didier Journois, M.D. Ph.D. · AP-HP, Université René Descartes

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2012-02-29
Completion
2012-02-29

Countries

  • France

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01104896 on ClinicalTrials.gov