Trial Outcomes & Findings for Enhancing Attention in Adults With Compulsive Hoarding (NCT NCT01100268)

Results Overview

Patients given Attention Deficit Hyperactivity Disorder Symptom Scale (ADHDSS), a measure of the features of Attention Deficit Hyperactivity Disorder including inattention, hyperactivity, and impulsivity. This scale has shown excellent reliability in prior studies of individuals with HD. For the ADHDSS the minimum units are 0 and Maximum units on the total scale are 54 (adult). The higher the number on the ADHDSS, the more severe the symptoms. Response was defined as at least a 30% reduction on the ADHDSS.

Recruitment status

COMPLETED

Study phase

PHASE2

Target enrollment

4 participants

Primary outcome timeframe

4 weeks

Results posted on

2014-09-18

Participant Flow

Dates of recruitment period are: April 2010-July 2010 Location: Outpatient clinic

Participant milestones

Participant milestones
Measure	Methylphenidate ER Subjects will start at 18mg/day; the dose will be increased in increments of 18mg per week to reach 72mg/day.
Overall Study STARTED	4
Overall Study COMPLETED	4
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Enhancing Attention in Adults With Compulsive Hoarding

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Methylphenidate ER n=4 Participants Subjects will start at 18mg/day; the dose will be increased in increments of 18mg per week to reach 72mg/day.
Age, Categorical <=18 years	0 Participants n=99 Participants
Age, Categorical Between 18 and 65 years	4 Participants n=99 Participants
Age, Categorical >=65 years	0 Participants n=99 Participants
Age, Continuous	43 years STANDARD_DEVIATION 5 • n=99 Participants
Sex: Female, Male Female	3 Participants n=99 Participants
Sex: Female, Male Male	1 Participants n=99 Participants
Region of Enrollment United States	4 participants n=99 Participants

PRIMARY outcome

Timeframe: 4 weeks

Patients given Attention Deficit Hyperactivity Disorder Symptom Scale (ADHDSS), a measure of the features of Attention Deficit Hyperactivity Disorder including inattention, hyperactivity, and impulsivity. This scale has shown excellent reliability in prior studies of individuals with HD. For the ADHDSS the minimum units are 0 and Maximum units on the total scale are 54 (adult). The higher the number on the ADHDSS, the more severe the symptoms. Response was defined as at least a 30% reduction on the ADHDSS.

Outcome measures

Outcome measures
Measure	Methylphenidate ER n=4 Participants Subjects will start at 18mg/day; the dose will be increased in increments of 18mg per week to reach 72mg/day.
Number of Patients Who Met and Exceeded Response Criteria of Attention Deficit Hyperactivity Disorder Symptom Scale	4 participants

SECONDARY outcome

Timeframe: 4 weeks

Patients given Saving Inventory-Revised (SI-R), an evidence-based measure of three features of hoarding: excessive acquisition, difficulty discarding, and clutter. For the SI-R the minimum units are 0 and Maximum units on the total scale are 92. The higher the number on the SI-R, the more severe the symptoms. Response was defined as at least a 25% reduction on the SI-R.

Outcome measures

Outcome measures
Measure	Methylphenidate ER n=4 Participants Subjects will start at 18mg/day; the dose will be increased in increments of 18mg per week to reach 72mg/day.
Number of Patients Who Met Response Criteria for the Saving Inventory-Revised.	2 participants

Adverse Events

Methylphenidate ER

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Carolyn Rodriguez

Columbia University Department of Psychiatry

Phone: (646) 774-8061

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place