Heart Biomarker Evaluation in Apnea Treatment

Summary

This study examines the role of sleep apnea treatment in improving cardiovascular biomarkers.

Conditions

• Cardiovascular Disease
• Obstructive Sleep Apnea
• Coronary Artery Disease

Interventions

OTHER

Healthy Lifestyles and Sleep Education plus PAP

Participants randomized to this arm will be educated on PAP and then use PAP for 3 months. They will also receive optimized medical preventive therapy according to current American Heart Association guidelines for prevention of CVD and sleep guidelines.

OTHER

Healthy Lifestyles and Sleep Education plus Supplemental Oxygen

Participants randomized to this arm will be educated on nocturnal supplemental oxygen and then use oxygen for 3 months. They also will receive optimized medical preventive therapy according to current American Heart Association guidelines for prevention of CVD and sleep guidelines.

OTHER

Healthy Lifestyles and Sleep Education

Participants randomized to this arm will receive optimized medical preventive therapy according to current American Heart Association guidelines for prevention of CVD and sleep guidelines.

Sponsors & Collaborators

• Case Western Reserve University

  collaborator OTHER

• Partners HealthCare

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• VA Boston Healthcare System

  collaborator FED

• Brigham and Women's Hospital

  lead OTHER

Principal Investigators

• Susan Redline, MD, MPH · Brigham and Women's Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

45 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-02-28

Primary Completion

2012-01-31

Completion

2012-08-31

Countries

• United States

Study Locations