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Bronchodilator Responsiveness in Healthy Young Adults Using Forced Oscillations Technique (FOT)

NCT01067534 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2011-01-19

No results posted yet for this study

Summary

Studies evaluating response to bronchodilation in flow-volume spirometry and/or by forced oscillations technique (FOT), have been conduced in subjects with obstructive airways diseases. Less is known about bronchodilation responses, assessed by both spirometry and FOT in healthy young subjects.

The purpose of the present study is

1. to determine the range of the bronchodilation response in terms of changes in selected spirometric parameters in healthy non-smoking young adults, for identifying normal response after an inhaled bronchodilatory agent versus placebo, and its anthropometric and spirometric determinants
2. to determine the range and characteristics of bronchodilation response using pseudorandom FOT in healthy non-smoking young adults, for identifying normal response after an inhaled bronchodilatory agent versus placebo, and its anthropometric and oscillometric determinants.
3. to compare and correlate eventual changes in spirometric and oscillometric parameters.

The investigators hypothesize that exists a normal variation in spirometric and oscillometric parameters after bronchodilation, and that these parameters are correlated.

Conditions

  • Bronchodilation

Interventions

DRUG

Salbutamol

Inhaler salbutamol 0,1 mg/dose - 4 doses=0,4 mg

Sponsors & Collaborators

  • University of Patras

    lead OTHER

Principal Investigators

  • Michael Anthracopoulos, MD · University Hospital of Patras, Greece

  • Sotirios Fouzas, MD · University Hospital of Patras, Greece

  • Konstantinos Bolis, MD · University Hospital of Patras, Greece

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2011-01-31
Completion
2011-01-31

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01067534 on ClinicalTrials.gov