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Bupivacaine Versus Lidocaine on Inflammatory Regulation

NCT01060774 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2018-05-31

No results posted yet for this study

Summary

This study is testing a local anesthetic (numbing medicine) to suppress pain. Bupivacaine and lidocaine are FDA approved local anesthetics that may decrease pain following surgery. Patients will receive either 2% lidocaine, 0.5% bupivacaine, or placebo with epinephrine 1:200,000 as a numbing medicine at the end of root canal surgery. Small pieces of gum will be taken before and after surgery and 2 days later to analyze chemicals that may be related to pain sensation.

Conditions

Interventions

DRUG

Lidocaine

Up to 5 capsules of 2% lidocaine with epinephrine as a reinforcement drug post-operatively

DRUG

Bupivacaine

Up to 5 capsules of 0.5% Bupivacaine with epinephrine given post-operatively.

Sponsors & Collaborators

  • University of Maryland

    lead OTHER

Principal Investigators

  • Sharon Gordon · University of Maryland, Baltimore College of Dental Surgery

  • Anastasia Mischenko · University of Maryland, Baltimore College of Dental Surgery

  • Morris Hicks · University of Maryland, Baltimore College of Dental Surgery

  • Ashraf Fouad · University of Maryland, Baltimore College of Dental Surgery

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-07-31
Primary Completion
2009-07-31
Completion
2010-07-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01060774 on ClinicalTrials.gov