Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) Trial

Summary

The purpose of this study is to compare the blood pressure lowering efficacy of a treatment regimen based on a dihydropyridine calcium-channel blocker combined with an angiotensin II type-1 receptor blocker with the recommended treatment regimen based on a low-dose thiazide diuretic combined with a beta-blocker.

Conditions

• Blood Pressure

Interventions

DRUG

amlodipine 5/10 mg per day plus valsartan 160 mg/day

Amlodipine 5/10 mg/day plus valsartan 160 mg/day, once daily, in the morning

DRUG

hydrochlorothiazide 6.25 mg/day plus bisoprolol 5/10 mg/day

hydrochlorothiazide 6.25 mg/day plus bisoprolol 5/10 mg/day, once daily, in the morning

Sponsors & Collaborators

• University of Kinshasa

  collaborator OTHER

• Yaounde Central Hospital

  collaborator OTHER_GOV

• University of Yaounde

  collaborator OTHER

• University of Libreville

  collaborator UNKNOWN

• Institute of Cardiology Abidjan

  collaborator UNKNOWN

• University of Ilorin Teaching Hospital

  collaborator OTHER

• University of Nigeria, Enugu Campus

  collaborator OTHER

• Hospital Aristide Le Dantec, Dakar, Senegal

  collaborator UNKNOWN

• KU Leuven

  lead OTHER

Principal Investigators

• Samuel Kingue, MD · Hôpital Général de Yaoundé, BP 5408, Yaoundé, Cameroun

• Daniel Lemogoum, MD, PhD · Université de Douala, Douala, Cameroon

• Bruno Mipinda, MD · Hôpital Central Universitaire de Libreville, Libreville, Gabon

• Omotoso Babatunde, MD · University of Ilorin, Ilorin, Nigeria

• Ifeoma E Ulasi, MD · University of Enugu, Enugu, Nigeria

• Serigne Abdou Ba, MD · Hôpital Aristide Le Dantec, Dakar, Sénégal

• Jean-René M'Buyamba-Kabangu, MD, PhD · University of Kinshasa, Kinshasa, Democratic Republic of Congo

• Jan A Staessen, MD, PhD · University of Leuven, Leuven, Belgium

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

30 Years

Max Age

69 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-09-30

Primary Completion

2012-03-31

Completion

2012-03-31

Countries

• Cameroon
• Côte d’Ivoire
• Gabon
• Nigeria
• Senegal

Study Locations