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Low Dose Radiation to Improve T-Cell Infiltration in Pancreatic Cancer

NCT01027221 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2021-06-10

No results posted yet for this study

Summary

Principal purpose of the study is the determination of an active local external beam radiotherapy dose leading to a maximum number of tumor infiltrating T-cells.

Conditions

  • Primarily Resectable Pancreatic Cancer

Interventions

RADIATION

neoadjuvant photon radiation

single fraction, four dimensions (4D) planned, image guided, Radiation at a dose of 0,5 Gy in Intensity modulated radiotherapy (IMRT)-technique 2 days before resection

RADIATION

neoadjuvant photon radiation

single fraction, 4D-planned, image guided, 2 Gy Radiation to the tumor with a safety margin, in IMRT-technique 2 days before resection

RADIATION

neoadjuvant photon radiation

single fraction, 4D-planned, image guided, 5 Gy Radiation to the tumor with a safety margin, in IMRT-technique 2 days before resection

Sponsors & Collaborators

  • Heidelberg University

    collaborator OTHER

  • German Cancer Research Center

    lead OTHER

Principal Investigators

  • Peter E. Huber, Prof. PhD MD · German Cancer Research Centre and Clinic for Radiation Oncology of the University of Heidelberg

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-11-30
Primary Completion
2019-09-30
Completion
2019-09-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01027221 on ClinicalTrials.gov