Studying Genes, Environment, and Prostate Cancer Risk in Patients With or Without Prostate Cancer

Summary

RATIONALE: Gathering information about genetic and environmental factors may help doctors learn more about a person's risk for developing prostate cancer.

PURPOSE: This research project is studying genes, environment, and prostate cancer risk in patients with or without prostate cancer.

Conditions

• Hereditary Prostate Cancer
• Prostate Cancer

Interventions

GENETIC

DNA analysis

saliva samples will be collected from men (probands) who join the study.

GENETIC

polymorphism analysis

we will genotype DNA samples (buccal) from all probands and conduct a traditional case-control analysis

OTHER

laboratory biomarker analysis

10ml blood specimen will be obtained and processed (on probands locally-consented and/or those who have an appointment at the VA in Portland, Oregon) to allow for analyses of erythrocyte fatty acids and future nutrient and DNA analyses

OTHER

medical chart review

PSA results, prostate biopsy pathology reports and clinician notes related to the biopsy are reviewed for final data analysis

OTHER

questionnaire administration

probands are asked to complete questionnaires on 1) family history of cancer, 2) diet history over the past year, 3) employment environment and risk factors and/or 4) changes to diet, medications since enrollment in originating case control study

PROCEDURE

evaluation of cancer risk factors

pathology reports will be reviewed for probands whose prostate biopsies reveal cancer; these factors will be evaluated for cancer risk factors

PROCEDURE

study of high risk factors

prostate biopsy pathology reports will be reviewed for high risk factors

Sponsors & Collaborators

• Portland VA Medical Center

  lead FED

Principal Investigators

• Jackilen Shannon, PhD · Portland VA Medical Center

Eligibility

Min Age

21 Years

Max Age

120 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2008-07-31

Primary Completion

2012-12-31

Completion

2012-12-31

Countries

• United States

Study Locations