Trial Outcomes & Findings for Surgical or Exercise Therapy on Patients With Degenerative Meniscus Tears (NCT NCT01002794)

Results Overview

The Knee Injury and Osteoarthritis Outcome Score (KOOS) is a patient administered questionnaire containing 42 questions in 5 subscales concerning patient´s knee related pain, other knee symptoms, activity of daily life, sport and recreation and quality of life.Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale. KOOS4 is a composite score of the mean values of four of the five KOOS subscales (KOOS Pain, KOOS Symptoms, KOOS Sport/Rec and KOOS QOL).

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

140 participants

Primary outcome timeframe

24 months

Results posted on

2024-07-29

Participant Flow

Participant milestones

Participant milestones
Measure	Arthroscopic Partial Meniscectomy Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Overall Study STARTED	70	70
Overall Study Three Months	60	63
Overall Study One Year	61	59
Overall Study Two Years	64	62
Overall Study Five Years	62	58
Overall Study COMPLETED	62	58
Overall Study NOT COMPLETED	8	12

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Surgical or Exercise Therapy on Patients With Degenerative Meniscus Tears

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Arthroscopic Partial Meniscectomy n=70 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=70 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum	Total n=140 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Age, Categorical Between 18 and 65 years	70 Participants n=99 Participants	70 Participants n=107 Participants	140 Participants n=206 Participants
Age, Categorical >=65 years	0 Participants n=99 Participants	0 Participants n=107 Participants	0 Participants n=206 Participants
Age, Continuous	48.9 years n=99 Participants	50.2 years n=107 Participants	49.6 years n=206 Participants
Sex: Female, Male Female	27 Participants n=99 Participants	27 Participants n=107 Participants	54 Participants n=206 Participants
Sex: Female, Male Male	43 Participants n=99 Participants	43 Participants n=107 Participants	86 Participants n=206 Participants
Region of Enrollment Norway	70 participants n=99 Participants	70 participants n=107 Participants	140 participants n=206 Participants

PRIMARY outcome

Timeframe: 24 months

The Knee Injury and Osteoarthritis Outcome Score (KOOS) is a patient administered questionnaire containing 42 questions in 5 subscales concerning patient´s knee related pain, other knee symptoms, activity of daily life, sport and recreation and quality of life.Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale. KOOS4 is a composite score of the mean values of four of the five KOOS subscales (KOOS Pain, KOOS Symptoms, KOOS Sport/Rec and KOOS QOL).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=64 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=62 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS4 - Change From Baseline	24.4 units on a scale Interval 20.7 to 28.0	25.3 units on a scale Interval 21.6 to 29.0

PRIMARY outcome

Timeframe: at 3 months

Peak torque knee extension (Newton meter) - Change from baseline

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=60 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=63 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Peak Torque Knee Extension - Change From Baseline	-2.63 Newton meter Interval -8.7 to 3.4	20.7 Newton meter Interval 14.7 to 26.7

PRIMARY outcome

Timeframe: 3 months

Peak torque knee flexion (Newton meter) - Change from baseline

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=60 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=63 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Peak Torque Knee Flexion - Change From Baseline	5.0 Newton meter Interval 1.6 to 8.4	12.8 Newton meter Interval 9.4 to 16.2

PRIMARY outcome

Timeframe: 5 years

In line with baseline assessment of the tibiofemoral joint, standing radiographs of the tibiofemoral joint is taken bilaterally with a Synaflexer Frame (Synarc Inc) that ensure alignment of the x-ray beam and standardize the placement of the knee in approximately 20 degrees of flexion and 5 degrees of external rotation for an anterior-posterior view. A sagittal view is also taken with the knee in flexion. Kellgren and Lawrence will be used for classification in addition to description of osteophytes and joint Space narrowing (JSN) will be measured.

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=62 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=58 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Knee Osteoarthritis Incidence	10 Participants	9 Participants

PRIMARY outcome

Timeframe: 10 years

Radiographic progression based on the sum of marginal tibiofemoral osteophyte grades and tibiofemoral joint space narrowing (the Osteoarthritis Research Society International \[OARSI\] atlas) \[Time Frame: At 10 years\]

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 3 months

Change in distance (meters) hopped on the One leg hop test from baseline to three months (higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=60 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=63 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
One Leg Hop Test - Change From Baseline	6.1 Meters Interval 1.4 to 10.8	11.0 Meters Interval 6.4 to 15.7

SECONDARY outcome

Timeframe: 3 months

Change in time (seconds) on the 6 meter timed hop test from baseline to 3 months (lower is better)

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=60 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=63 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
6 Meter Timed Hop Test - Change From Baseline	-0.1 Seconds Interval -0.4 to 0.1	-0.5 Seconds Interval -0.8 to -0.3

SECONDARY outcome

Timeframe: 3 months

Change in number of repetitions performed on the Knee bends 30 seconds test from baseline to 3 months (higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=60 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=63 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Knee Bends 30 Sec - Change From Baseline	8.5 Number of repetitions Interval 6.6 to 10.4	9.9 Number of repetitions Interval 8.1 to 11.8

SECONDARY outcome

Timeframe: 1 year

Change in Peak torque knee extension (Newton meter) from baseline to 12 months (higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=61 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=59 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Peak Torque Knee Extension - Change From Baseline	8.8 Newton meter Interval 2.8 to 14.8	18.2 Newton meter Interval 12.1 to 24.4

SECONDARY outcome

Timeframe: 12 months

Change in Peak torque knee flexion (Newton meter) from baseline to 12 months (higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=61 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=59 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Peak Torque Knee Flexion - Change From Baseline	4.3 Netwon meter Interval 0.9 to 7.7	11.4 Netwon meter Interval 7.9 to 14.8

SECONDARY outcome

Timeframe: 12 months

Change in distance (meters) hopped on the One leg hop test from baseline to 12 months (higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=61 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=59 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
One-leg Hop Test - Change in From Baseline	13.1 Meters Interval 8.3 to 17.8	13.2 Meters Interval 8.4 to 17.9

SECONDARY outcome

Timeframe: 12 months

Change in time (seconds) on the 6 meter timed hop test from baseline to 12 months (lower is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=61 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=59 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
6 Meter Timed Hop Test - Change From Baseline	-0.3 Seconds Interval -0.5 to 0.0	-0.6 Seconds Interval -0.8 to -0.4

SECONDARY outcome

Timeframe: 12 months

Change in number of repetitions performed on the Knee bends 30 seconds test from baseline to 12 months (higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=61 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=59 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Knee Bends 30 Sec - Change From Baseline	10.6 Number of repetitions Interval 8.7 to 12.5	9.2 Number of repetitions Interval 7.3 to 11.1

SECONDARY outcome

Timeframe: 24 months

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale.

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=64 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=62 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS Pain - Change From Baseline	21.7 units on a scale Interval 18.0 to 25.5	23.2 units on a scale Interval 19.4 to 27.0

SECONDARY outcome

Timeframe: 24 months

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptoms subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale.

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=64 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=62 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS Symptoms - Change From Baseline	12.0 units on a scale Interval 8.7 to 15.4	17.4 units on a scale Interval 14.0 to 20.9

SECONDARY outcome

Timeframe: 24 months

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Activities in Daily Living (ADL) subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=64 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=62 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS ADL - Change From Baseline	13.8 units on a scale Interval 10.7 to 16.9	15.4 units on a scale Interval 12.2 to 18.6

SECONDARY outcome

Timeframe: 24 months

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sport and recreation (Sport/Rec) subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale.

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=64 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=62 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS Sport/Rec - Change From Baseline	30.8 units on a scale Interval 25.4 to 36.1	29.3 units on a scale Interval 24.0 to 34.7

SECONDARY outcome

Timeframe: 24 months

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life (QOL) subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale.

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=64 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=62 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS QOL - Change From Baseline	33.1 units on a scale Interval 28.7 to 37.5	31.3 units on a scale Interval 26.8 to 35.7

SECONDARY outcome

Timeframe: 24 months

Change in Short form 36 mental component summary (SF-36 MCS) from baseline to 24 months (range: 0-100; higher is better)

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=64 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=62 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
SF-36 MCS - Change From Baseline	-0.3 units on a scale Interval -2.0 to 1.4	1.1 units on a scale Interval -1.1 to 3.3

SECONDARY outcome

Timeframe: 24 months

Change in Short form 36 physical component summary (SF-36 PCS) from baseline to 24 months (range: 0-100; higher is better)

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=64 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=62 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
SF-36 PCS - Change From Baseline	7.0 units on a scale Interval 5.3 to 8.6	5.5 units on a scale Interval 3.5 to 7.4

SECONDARY outcome

Timeframe: 5 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain subscale from baseline to five years (range: 0-100; higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=62 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=57 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS Pain Subscale - Change From Baseline	23.8 units on a scale Interval 20.1 to 27.5	21.3 units on a scale Interval 17.4 to 25.2

SECONDARY outcome

Timeframe: 5 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptoms subscale from baseline to five years (range: 0-100; higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=62 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=57 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS Symptoms Subscale - Change From Baseline	12.9 units on a scale Interval 9.1 to 16.7	13.2 units on a scale Interval 9.3 to 17.2

SECONDARY outcome

Timeframe: 5 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Activities of Daily Living (ADL) subscale from baseline to five years (range: 0-100; higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=62 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=57 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS ADL Subscale - Change From Baseline	14.5 units on a scale Interval 11.5 to 17.5	14.6 units on a scale Interval 11.5 to 17.8

SECONDARY outcome

Timeframe: 5 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sport and Recreation (Sport/Rec) subscale from baseline to five years (range: 0-100; higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=62 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=57 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS Sport/Rec Subscale - Change From Baseline	33.4 units on a scale Interval 27.5 to 39.3	29.0 units on a scale Interval 22.9 to 35.1

SECONDARY outcome

Timeframe: 5 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life (QOL) subscale from baseline to five years (range: 0-100; higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=62 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=57 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
KOOS QOL Subscale - Change From Baseline	34.4 units on a scale Interval 29.3 to 39.4	30.7 units on a scale Interval 25.5 to 36.0

SECONDARY outcome

Timeframe: 5 years

Change in body weight (kilograms) normalized Peak torque knee extension (Newton meter/kg) from baseline to five years (higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=59 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=57 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Peak Torque Knee Extension - Change From Baseline	0.03 Newton meters/kg Interval -0.05 to 0.1	0.13 Newton meters/kg Interval 0.05 to 0.2

SECONDARY outcome

Timeframe: 5 years

Change in body weight (kilograms) normalized Peak torque knee extension (Newton meter/kg) from baseline to five years (higher is better).

Outcome measures

Outcome measures
Measure	Arthroscopic Partial Meniscectomy n=59 Participants Standard arthroscopic partial meniscectomy - NGD 1 Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.	Exercise Therapy n=57 Participants Supervised neuromuscular- and strength training Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Peak Torque Knee Flexion - Change From Baseline	-0.02 Newton meters/kg Interval -0.07 to 0.02	0.04 Newton meters/kg Interval 0.0 to 0.09

SECONDARY outcome

Timeframe: 10 years

Knee osteoarthritis incidence (Kellgren and Lawrence classification) \[ Time Frame: 10 years\]

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 10 years

Change in KOOS4 from baseline to 10 years (range: 0-100; higher is better). KOOS4 is a composite score of the mean values of four of the five Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales (KOOS Pain, KOOS Symptoms, KOOS Sport/Rec and KOOS QOL).

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 10 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain subscale from baseline to 10 years (range: 0-100; higher is better).

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 10 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptoms subscale from baseline to 10 years (range: 0-100; higher is better).

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 10 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Activities of Daily Living (ADL) subscale from baseline to 10 years (range: 0-100; higher is better).

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 10 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sport and recreation (Sport/Rec) subscale from baseline to five years (range: 0-100; higher is better).

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 10 years

Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life (QOL) subscale from baseline to ten years (range: 0-100; higher is better).

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 10 years

Change in body weight (kilograms) normalized Peak torque knee flexion (Newton meter/kg) from baseline to ten years (higher is better).

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 10 years

Change in body weight (kilograms) normalized Peak torque knee extension (Newton meter/kg) from baseline to 10 years (higher is better).

Outcome measures

Outcome data not reported

Adverse Events

Arthroscopic Partial Meniscectomy

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Exercise Therapy

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Professor May Arna Risberg

Oslo University Hospital

Phone: +4741312776

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place