A Study of MM-121 Combination Therapy in Patients With Advanced Non-Small Cell Lung Cancer
NCT00994123 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 162
Last updated 2016-08-22
Summary
A Phase 1-2 study of MM-121 in combination with standard therapy for non-small cell lung cancer (NSCLC).
Conditions
- Carcinoma, Non-Small-Cell Lung
Interventions
- DRUG
-
MM-121
MM-121 (SAR256212) = intravenous solution
- DRUG
-
Erlotinib
erlotinib = daily oral tablet
Sponsors & Collaborators
-
Merrimack Pharmaceuticals
lead INDUSTRY
Principal Investigators
-
Victor Moyo, MD · Merrimack Pharmaceuticals
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2010-02-28
- Primary Completion
- 2014-11-30
- Completion
- 2015-06-30
Countries
- United States
- Canada
- Germany
- South Korea
- Spain
- Taiwan
Study Locations
More Related Trials
-
A Randomized Phase 2 Study of Erlotinib + ARQ 197 Versus Erlotinib + Placebo in Previously Treated Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT00777309 ·Status: COMPLETED ·Phase: PHASE2
-
Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy
NCT04691817 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of Erlotinib [Tarceva] as Monotherapy or Intermittent Dosing With Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer. (TALISMAN)
NCT01204697 ·Status: COMPLETED ·Phase: PHASE2
-
Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Followed by Radiation Therapy and Erlotinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery
NCT00553462 ·Status: COMPLETED ·Phase: PHASE2
-
Erlotinib Is Being Studied With Or Without An Investigational Drug, PF-02341066, In Patients With Lung Cancer
NCT00965731 ·Status: COMPLETED ·Phase: PHASE1
-
Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer
NCT00126581 ·Status: COMPLETED ·Phase: PHASE2
-
S0341: Erlotinib in Treating Patients With Advanced Primary Non-Small Cell Lung Cancer
NCT00087412 ·Status: COMPLETED ·Phase: PHASE2
-
Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study
NCT03381274 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Randomized Phase 2 Study of AT-101 in Combination With Docetaxel in Relapsed/Refractory Non-Small Cell Lung Cancer
NCT00544960 ·Status: COMPLETED ·Phase: PHASE2
-
PF-00299804 As A Single Agent, In Patients With Advanced Non-Small Cell Lung Cancer Who Have Failed Chemotherapy And Erlotinib
NCT00548093 ·Status: COMPLETED ·Phase: PHASE2
-
A Study for Non-Smoker Patients With Nonsquamous Non-Small Cell Lung Cancer
NCT00550173 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of MM-121 in Combination With Chemotherapy Versus Chemotherapy Alone in Heregulin Positive NSCLC
NCT02387216 ·Status: TERMINATED ·Phase: PHASE2
-
National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer
NCT02664935 ·Status: COMPLETED ·Phase: PHASE2
-
Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancer
NCT03600701 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study of Everolimus With Paclitaxel and Carboplatin in Patients With Metastatic Melanoma
NCT01014351 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of MetMAb Administered to Patients With Advanced Non-Small Cell Lung Cancer, in Combination With Tarceva (Erlotinib)
NCT00854308 ·Status: COMPLETED ·Phase: PHASE2
-
Erlotinib and Docetaxel in Second Line of Treatment in Patients With Non Small Cell Lung Cancer
NCT01350817 ·Status: COMPLETED ·Phase: PHASE2
-
Trial of PM02734 Administered in Combination With Erlotinib in Patients With Advanced Malignant Solid Tumors
NCT00884845 ·Status: COMPLETED ·Phase: PHASE1
-
Combination of RAD001 and Erlotinib in Patients With Advanced Non Small Cell Lung Cancer Previously Treated Only With Chemotherapy
NCT00456833 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of Pembrolizumab Plus Investigational Agents in Combination With Chemotherapy as First-Line Treatment in Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (MK-3475-B99/ KEYNOTE-B99)
NCT04924101 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of First-line Maintenance Erlotinib Versus Erlotinib at Disease Progression in Participants With Advanced Non-Small Cell Lung Cancer (NSCLC) Who Have Not Progressed Following Platinum-Based Chemotherapy
NCT01328951 ·Status: COMPLETED ·Phase: PHASE3
-
2nd Line Erlotinib Treatment With (Out) Chemotherapy of Advanced Non Small Cell Lung Cancer (NSCLC)
NCT00835471 ·Status: COMPLETED ·Phase: PHASE2
-
Erlotinib and Radiation Therapy Plus Combination Chemotherapy in Treating Patients With Inoperable Stage III Non-Small Cell Lung Cancer
NCT00042835 ·Status: TERMINATED ·Phase: PHASE1
-
Phase I Imaging Study Evaluating Dalotuzumab (MK0646) in Combination With Erlotinib for Patients With Non-Small Cell Lung Cancer (MK-0646-008)
NCT00729742 ·Status: COMPLETED ·Phase: PHASE1
-
Trial Of Erlotinib With Or Without PF-3512676 In Advanced Non Small Cell Lung Cancer
NCT00321815 ·Status: COMPLETED ·Phase: PHASE2