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Determinants of Fetal Inflammatory Exposure at Term

NCT00970151 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 618

Last updated 2009-10-12

No results posted yet for this study

Summary

The hypothesis of this study is that maternal and fetal biologic variation in the balance between pro-inflammatory and anti-inflammatory mediators can be measured by currently available techniques. In addition, the investigators hypothesize that a pro-inflammatory maternal phenotype increases the risk of fetal exposure to intrauterine hyperthemia and inflammatory cytokines; and that intrapartum events, especially known risk factors for fever at term such as epidural analgesia and prolonged rupture of membranes, may interact with underlying maternal factors to increase fetal exposure to inflammatory cytokines.

This experiment aims to establish the first large-scale cohort to evaluate biomarkers for maternal and fetal inflammation in term pregnancy and to elucidate the relative antepartum and intrapartum contributions to fetal inflammation.

Conditions

  • Maternal-Fetal Relations

Sponsors & Collaborators

  • March of Dimes

    collaborator OTHER

  • Medical University of South Carolina

    lead OTHER

Principal Investigators

  • Laura Goetzl, MD · Medical University of South Carolina

Eligibility

Min Age
14 Years
Max Age
48 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-06-30
Primary Completion
2009-08-31
Completion
2009-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00970151 on ClinicalTrials.gov