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Role of Prostaglandins on Niacin-Induced Flushing

NCT00930839 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2010-03-10

No results posted yet for this study

Summary

This study will focus on investigating the nicotinic acid stimulated release of prostaglandin D2 in normal controls. In subsequent studies, the investigators would like to further explore this pathway in people with type 2 diabetes. Enhanced blood flow (or flushing) may be compromised or exaggerated in type 2 diabetes particularly in those with impairment of autonomic function measured as the respiratory heart rate variability (HRV) of different frequencies reflecting the balance between the sympathetic and parasympathetic nervous systems. The investigators hypothesize that the vasodilatory effects induced by nicotinic acid will be different in glabrous and hairy skin and that autonomic imbalance may alter the response.

Conditions

  • Flushing

Interventions

DRUG

Niacin and aspirin

1000 mg Niacin, 325 mg aspirin

Sponsors & Collaborators

  • Abbott

    collaborator INDUSTRY

  • Eastern Virginia Medical School

    lead OTHER

Principal Investigators

  • Aaron I Vinik, MD, PhD · Eastern Virginia Medical School, Strelitz Diabetes Center

Eligibility

Min Age
30 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-03-31
Primary Completion
2010-02-28
Completion
2010-02-28

Countries

  • United States

Study Locations

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Entities

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00930839 on ClinicalTrials.gov