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Metabolic Acidosis in Renal Transplant Patients

NCT00913796 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2010-10-22

No results posted yet for this study

Summary

Acidosis (accumulation of acid in the body) may be an underrecognized problem in patients after renal transplantation. It may have consequences on physical performance due to negative effects on bone and muscle metabolism.

Therefore, the purpose of this study is

1. to determine the status of physical capacity and bone structure in renal transplant patients with metabolic acidosis
2. to study the effect of substituting base equivalents (citrate) on acid/base status of renal transplant patients with acidosis
3. to compare the status of physical capacity and bone structure in renal transplant patients with metabolic acidosis before and after substitution with citrate

Conditions

  • Renal Transplant Patients
  • Metabolic Acidosis
  • Physical Capacity
  • Bone Disease
  • Mineral Metabolism

Interventions

DRUG

Potassium citrate

2.41 gram of citrate b.i.d. for 12 months. Dosage to be adjusted according to serum potassium concentration.

DRUG

Potassium chloride

370 mg potassium t.i.d. for 12 months. Dosage to be adjusted according to serum postassium concentration.

Sponsors & Collaborators

  • University of Texas Southwestern Medical Center

    collaborator OTHER

  • Swiss Federal Institute of Technology

    collaborator OTHER

  • University of Zurich

    lead OTHER

Principal Investigators

  • Patrice M. Ambühl, M.D. · University of Zurich

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-12-31
Primary Completion
2010-03-31
Completion
2010-03-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00913796 on ClinicalTrials.gov