Case Control Study of Pharmacogenomic Factors Associated With Hepatocellular Injury Following Exposure to Lapaquistat Acetate

A Study to Investigate the Effect of Mild and Moderate Hepatic Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Hepatic Function

NCT04482270 ·Status: COMPLETED ·Phase: PHASE1

Study to Evaluate a Dose of Telotristat Etiprate in Male and Female With Mild, Moderate and Severe Hepatic Insufficiency and Matched Healthy Subjects

NCT02683577 ·Status: COMPLETED ·Phase: PHASE1

Impact of Hepatic Impairment on the Pharmacokinetics of Deferasirox.

NCT00432627 ·Status: COMPLETED ·Phase: PHASE1

A Study to Learn About the Study Medicine (Called Lorlatinib) in People With Liver Dysfunction

NCT05224609 ·Status: COMPLETED ·Phase: PHASE1

Effect of Moderate Hepatic Impairment on the Pharmacokinetics and Metabolism of a Single Dose of Licarbazepine

NCT00424671 ·Status: COMPLETED ·Phase: PHASE1

Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Hepatic Function

NCT02412098 ·Status: COMPLETED ·Phase: PHASE1

Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects

NCT02318836 ·Status: COMPLETED ·Phase: PHASE1

A Single-dose, Open-label, Pharmacokinetic Study of Belapectin (GR-MD-02) in Subjects With Normal Hepatic Function and Subjects With Varying Degrees of Hepatic Impairment

NCT04332432 ·Status: COMPLETED ·Phase: PHASE1

Study to Evaluate the Pharmacokinetics of Telotristat Ethyl in Subjects With Severe Hepatic Impairment

NCT03423446 ·Status: COMPLETED ·Phase: PHASE1

KD025 Hepatic Impairment Study With Normal Hepatic Function and Subjects With Varying Degrees of Hepatic Impairment

NCT04166942 ·Status: COMPLETED ·Phase: PHASE1

A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)

NCT02421042 ·Status: COMPLETED ·Phase: PHASE1

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function

NCT02170571 ·Status: COMPLETED ·Phase: PHASE1

Evaluation of the Pharmacokinetics of Tropifexor in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Healthy Control Subjects

NCT03681457 ·Status: COMPLETED ·Phase: PHASE1

Hepatic Impairment Trial of Obeticholic Acid

NCT01904539 ·Status: COMPLETED ·Phase: PHASE1

A Study to Evaluate the Effect of Hepatic Impairment on JNJ-42847922 in Adult Participants

NCT04960124 ·Status: COMPLETED ·Phase: PHASE1

Open Label Study of a Single Dose of a New Extended Long Acting Formulation of Octreotide Pamoate in Healthy Volunteers

NCT00432068 ·Status: COMPLETED ·Phase: PHASE1

Drug-induced Liver Injury: Itching Study

NCT06446609 ·Status: RECRUITING

Pharmacokinetics (PK) Study of Gepotidacin (GSK2140944) in Adult Subjects With Varying Degrees of Hepatic Impairment and in Matched Control Subjects With Normal Hepatic Function

NCT03562117 ·Status: COMPLETED ·Phase: PHASE1

Study to Investigate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of ACT-389949

NCT02099071 ·Status: COMPLETED ·Phase: PHASE1

Pharmacokinetic Properties of Lorcaserin in Subjects With Hepatic Impairment

NCT00828932 ·Status: COMPLETED ·Phase: PHASE1

Study on the Safety of Neladenoson Bialanate, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Dug Given as a Single Oral Dose in Participants With Liver Impairment and Healthy Participants Matched for Age-, Gender-, and Weight

NCT04322253 ·Status: TERMINATED ·Phase: PHASE1

The Effect of Hepatic Impairment on Aprocitentan Pharmacokinetics

NCT04252495 ·Status: COMPLETED ·Phase: PHASE1

MEK162 in Healthy Subjects With Normal Hepatic Function and Subjects With Impaired Hepatic Function

NCT02050815 ·Status: TERMINATED ·Phase: PHASE1

Pharmacogenetics Sampling of the CC-90007-CP-003 Study Cohort

NCT04097704 ·Status: COMPLETED

PK and Safety of Midostaurin in Subjects With Impaired Hepatic Function and Subjects With Normal Hepatic Function

NCT01429337 ·Status: COMPLETED ·Phase: PHASE1