JAK-STAT Signalling Pathway in Familial Myeloproliferative Disorders
NCT00873574 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 234
Last updated 2013-03-08
Summary
The main goal of the study is to progress in our understanding of the molecular basis of myeloproliferative disorders of the bone marrow (polycythemia vera, essential thrombocythemia, primary myelofibrosis). The study will focus on the genes encoding factors implicated in the JAK-STAT pathway which has an essential role in these diseases
Conditions
- Myeloproliferative Disorders
Interventions
- BIOLOGICAL
-
Blood samples and buccal swabs
Peripheral blood samples (35 ml) and buccal swabs
Sponsors & Collaborators
-
Assistance Publique - Hôpitaux de Paris
lead OTHER
Principal Investigators
-
Albert NAJMAN, MD PhD · Assistance Publique - Hôpitaux de Paris
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2008-09-30
- Primary Completion
- 2011-05-31
- Completion
- 2012-09-30
Countries
- France
Study Locations
More Related Trials
-
Ruxolitinib vs Allogeneic SCT for Patients With Myelofibrosis According to Donor Availability
NCT03333187 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders
NCT00006056 ·Status: UNKNOWN ·Phase: NA
-
Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders
NCT03579875 ·Status: RECRUITING ·Phase: PHASE2
-
Haplo-identical Transplantation in Patients With Myelofibrosis - A Phase 2 Prospective Multicentric Prospective Study
NCT04728490 ·Status: UNKNOWN ·Phase: PHASE2
-
Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major
NCT03171831 ·Status: UNKNOWN ·Phase: PHASE4
-
Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders
NCT03314974 ·Status: RECRUITING ·Phase: PHASE2
-
MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies
NCT05735717 ·Status: RECRUITING ·Phase: PHASE2
-
Ruxolitinib Pre-, During- and Post-HSCT for Patients With Primary or Secondary Myelofibrosis.
NCT03427866 ·Status: COMPLETED ·Phase: PHASE2
-
Observational Study of the Combination of Post-transplant High Dose Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Acute Graft-versus-Host Disease in Patients Eligible to Allogeneic Hematopoietic Stem Cell Transplant
NCT02300571 ·Status: UNKNOWN
-
Cyclophosphamide and/or Mycophenolate Mofetil With or Without Tacrolimus in Treating Patients Who Are Undergoing a Donor Bone Marrow or Peripheral Stem Cell Transplant for Hematologic Cancer
NCT00255710 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
NCT05531786 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Maintenance Fedratinib to Prevent Post-Transplant Relapse in Myeloproliferative Neoplasms
NCT05127174 ·Status: TERMINATED ·Phase: PHASE1
-
Luspatercept for Anemia in Lower Risk MDS or Non-proliferative MDS/MPN Neoplasms
NCT05732961 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Identification of Molecular Defects in Idiopathic Cytopenia of Undetermined Significance
NCT02804984 ·Status: UNKNOWN
-
Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies
NCT01028716 ·Status: TERMINATED ·Phase: PHASE2
-
Related Hematopoietic Stem Cell Transplantation (HSCT) for Genetic Diseases of Blood Cells
NCT02512679 ·Status: TERMINATED ·Phase: PHASE2
-
Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation
NCT03755414 ·Status: COMPLETED ·Phase: PHASE1
-
2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological Malignancies
NCT03712878 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)
NCT06351631 ·Status: RECRUITING ·Phase: PHASE3
-
Phase 2 Haplotype Mismatched HSCT in Patients With Hematological Malignancies
NCT00593554 ·Status: TERMINATED ·Phase: PHASE2
-
Extracorporeal Photopheresis Using Theraflex ECP™ for Patients With Refractory Chronic Graft Versus Host Disease (cGVHD)
NCT03083574 ·Status: UNKNOWN ·Phase: PHASE2
-
Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies
NCT02556931 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 2 Study of RO7490677 In Participants With Myelofibrosis
NCT01981850 ·Status: COMPLETED ·Phase: PHASE2
-
Reduced Intensity, Partially HLA Mismatched BMT to Treat Hematologic Malignancies
NCT01203722 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Results of Peripheral Blood Stem Cells According to Stimulatory Molecule,: Zarzio Versus Granocytes
NCT03367117 ·Status: COMPLETED