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Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients

NCT00873496 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2009-04-01

No results posted yet for this study

Summary

Chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and xerostomia in Sjögren's syndrome. The oral consequences range widely and they are related to decreased salivary output. Hydroxychloroquine may inhibit cholinesterase activity in salivary glands via interference with antigen processing mechanism, and thus, the investigators' hypothesis was that salivary gland function may be improved if treated with hydroxychloroquine. The effects of hydroxychloroquine on the salivary flow rate, subjective and objective parameters of the patients were also assessed.

Conditions

  • Sjögren's Syndrome
  • Xerostomia

Interventions

DRUG

Hydroxychloroquine

Sponsors & Collaborators

  • Ege University

    lead OTHER

Principal Investigators

  • Esin Alpoz · Ege University School of Dentistry

Eligibility

Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-01-31
Primary Completion
2008-10-31
Completion
2009-01-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00873496 on ClinicalTrials.gov