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Cranial Radiotherapy or Intensive Chemotherapy With Hematopoietic Stem Cell Rescue for Primary Central Nervous System Lymphoma in Young Patients

NCT00863460 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 140

Last updated 2019-02-05

No results posted yet for this study

Summary

Purpose of the study :

To evaluate the antitumoral effect of two therapeutic procedures and to evaluate their respective toxicity on the CNS.

Conditions

Interventions

RADIATION

cranial radiotherapy

40 Gy

DRUG

intensive chemotherapy and hematopoietic stem cell rescue

intensive chemotherapy and hematopoietic stem cell rescue

DRUG

MTX based chemotherapy

R-MBVP 2 cycles day1 and day28 followed by R-Aracytine 2 cycles days58\&59 and days79\&80

Sponsors & Collaborators

  • Ministry of Health, France

    collaborator OTHER_GOV

  • Hoffmann-La Roche

    collaborator INDUSTRY

  • Amgen

    collaborator INDUSTRY

  • Pierre Fabre Laboratories

    collaborator INDUSTRY

  • Institut Curie

    lead OTHER

Principal Investigators

  • Carole Soussain, MD · Institut Curie - Hôpital René Huguenin

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-10-03
Primary Completion
2016-05-17
Completion
2026-05-31

Countries

  • France

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00863460 on ClinicalTrials.gov