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Switching From One Type of Anti-rejection Drug (Tacrolimus or Cyclosporine) to Another (Sirolimus) Approximately 90-180 Days After Liver Transplantation

NCT00834496 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2017-01-12

No results posted yet for this study

Summary

Sirolimus can be safely switched as early as 90 days after liver transplantation with excellent tolerability and amelioration of the calcineurin inhibitor toxicity that initiated the switch.

Conditions

  • Side Effects of Calcineurin Inhibitors
  • Renal Toxicity
  • Hepatic Fibrosis on Biopsy
  • Neurotoxicity
  • Post Transplant Diabetes

Interventions

PROCEDURE

Liver biopsy

percutaneous liver biopsy

Sponsors & Collaborators

  • Wyeth is now a wholly owned subsidiary of Pfizer

    collaborator INDUSTRY

  • Thomas Jefferson University

    lead OTHER

Principal Investigators

  • Cataldo Doria, MD, PhD · Thomas Jefferson University and Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-01-31
Primary Completion
2010-01-31
Completion
2010-01-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00834496 on ClinicalTrials.gov