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The PostprAndial eNdothelial Function After Combination of Ezetimibe and simvAstatin Study

NCT00817843 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2013-01-09

Study results available
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Summary

The purpose of this study is to investigate whether low-dose simvastatin in combination with ezetimibe in comparison to high-dose simvastatin alone, has a beneficial effect on the function of the endothelium after an oral fat load in patients with metabolic syndrome.

Conditions

  • Metabolic Syndrome

Interventions

DRUG

Simvastatin

6 weeks of treatment with simvastatin 80 mg

DRUG

Simvastatin/Ezetimibe

6 weeks of treatment with simvastatin 10 mg / ezetimibe 10 mg combination

Sponsors & Collaborators

Principal Investigators

  • Frank LJ Visseren, MD PhD · UMC Utrecht

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
79 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-04-30
Primary Completion
2010-09-30
Completion
2010-09-30

Countries

  • Netherlands
  • Spain

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00817843 on ClinicalTrials.gov