A Clinical Trial of Cytotoxic T Cells Augmenting Autologous Hematopoietic Stem Cell (AHSC) Transplantation for Acute Myeloid Leukemia (AML)
NCT00808080 · Status: TERMINATED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 6
Last updated 2019-04-09
Summary
The aim of this protocol is to investigate a novel form of immune therapy for patients with acute myelogenous leukemia (AML) who are in remission (CR) but who are at high risk for relapse.
Conditions
Interventions
- BIOLOGICAL
-
AMLCTL
Ex-vivo expanded cytotoxic autologous AML-reactive T cells (CTL)
Sponsors & Collaborators
-
Thomas A. Lane, MD
lead OTHER
Principal Investigators
-
Thomas Lane, MD · UCSD
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2010-01-31
- Primary Completion
- 2013-06-30
- Completion
- 2013-06-30
Countries
- United States
Study Locations
More Related Trials
-
Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant
NCT02038153 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia
NCT01801046 ·Status: TERMINATED ·Phase: PHASE1
-
High Dose Donor Hematopoietic Stem Cell Infusion for Relapsed/Refractory AML
NCT03080922 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Leukemia Stem Cell Detection in Acute Myeloid Leukemia
NCT02927938 ·Status: TERMINATED ·Phase: PHASE3
-
Vaccine Therapy With or Without Donor Lymphocyte Infusion in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Multiple Myeloma Undergoing Donor Stem Cell Transplant
NCT00469820 ·Status: TERMINATED ·Phase: PHASE1
-
Donor Cellular Therapy After Cytarabine in Treating Patients With Intermediate-Risk Acute Myeloid Leukemia in Remission
NCT02587871 ·Status: WITHDRAWN ·Phase: PHASE2
-
Allogeneic HCT Using Nonmyeloablative Host Conditioning With TLI & ATG vs SOC in AML
NCT00568633 ·Status: TERMINATED ·Phase: PHASE3
-
Therapy of Relapsed AML With Chemotherapy and Dendritic Cell Activated Lymphocytes
NCT00038870 ·Status: WITHDRAWN ·Phase: NA
-
ADCT-301 in Patients With R/R AML, MDS, or MDS/MPN
NCT04639024 ·Status: TERMINATED ·Phase: PHASE2
-
Analysis of T Cell Metabolism in Acute Myeloid Leukemia Patients
NCT04259372 ·Status: COMPLETED
-
Immediate Allogeneic Hematopoietic Stem Cell Transplantation Versus Re-treatment for Patients With High-Risk Acute Myeloid Leukemia
NCT06643195 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Efficacy of Integrated Induction-Consolidation Chemotherapy and Transplantation for Adult Acute Myeloid Leukemia: Multicenter Study
NCT07108530 ·Status: RECRUITING ·Phase: PHASE2
-
Transfusion in Adult Acute Myeloid Leukemia
NCT02899767 ·Status: COMPLETED
-
QUILT-3.034: Non-Myeloablative TCRa/b Deplete Haplo HSCT With Post ALT-803 for AML
NCT03365661 ·Status: WITHDRAWN ·Phase: PHASE2
-
Vaccine Therapy in Treating Patients With Acute Myeloid Leukemia
NCT00100971 ·Status: TERMINATED ·Phase: PHASE1
-
Characterization of T-cell Repertoire in Patients With Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant
NCT03921047 ·Status: RECRUITING
-
Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation
NCT02632708 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics and Efficacy of AZD1208 in Acute Myelogenous Leukemia (AML) Patients
NCT01489722 ·Status: TERMINATED ·Phase: PHASE1
-
Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission
NCT00002514 ·Status: COMPLETED ·Phase: PHASE3
-
Sequential Conditioning in Haploidentical Transplantation for Refractory Acute Myeloid Leukemia
NCT03035422 ·Status: COMPLETED ·Phase: NA
-
Lenalidomide in Combination With Microtransplantation as Post-remission Therapy in AML
NCT02255162 ·Status: TERMINATED ·Phase: PHASE1
-
Study of Adoptive Cellular Therapy Using Autologous T Cells Transduced With Lentivirus to Express a CD33 Specific Chimeric Antigen Receptor in Patients With Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia
NCT03126864 ·Status: TERMINATED ·Phase: PHASE1
-
Multicenter Study of Combined Chemotherapy and Transplantation for Adult ALL
NCT07059156 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Treatment of Elderly AML Patients With Induction Chemotherapy Followed by G-CSF-Mobilized Stem Cells From Haploidentical Related Donors
NCT02519712 ·Status: TERMINATED ·Phase: NA
-
Safety and Immunogenicity of Recombinant WT1 Antigen-Specific Cancer Immunotherapeutic Combined With Infusion of Treg Depleted T Cells for Adult WT1 Acute Myeloid Leukemia
NCT01513109 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2