The Efficacy and Safety of Low Dose Combination of LTG and VPA Compared to CBZ Monotherapy

Summary

To evaluate the efficacy of usual monotherapy and low dose combination of Lamotrigine and Valproate. Low dose combination may be more effective and tolerable because they are low dose and VPA reduce Lamotrigine metabolism.

Conditions

• Epilepsy

Interventions

DRUG

Carbamazepine

DRUG

Lamotrigine/Valproate

Sponsors & Collaborators

• Yonsei University

  lead OTHER

Principal Investigators

• Byung-In Lee · Yonsei Univ.

• Kyoung Heo · Yonsei Univ.

• Sang-Kun Lee · Seoul National Univ.

• Sang-Ahm Lee · Ulsan Univ.

• Dong-Jin Shin · Gacheon Univ.

• Hong-Ki Song · Hallym Univ.

• Young-In Kim · Catholic Univ.

• Se-Jin Lee · Youngnam Univ.

• Sang-Ho Kim · Donga Univ.

• Myung-Gyu Kim · Cheonnam Univ.

• Yo-Sik Kim · Wonkwang Univ.

• Sang-Do Lee · Dongsan Hosp.

• Sung-Eun Kim · Pusan-Bak Hosp.

• Sung-Pa Park · Kyungbuk Univ.

• Joo-Yong Kim · Hanrim Univ.

• Ok-Jun Kim · Bundang Cha

• Soon-Ki Noh · Bong-Sang Hosp.

• Hyang-Woon Lee · I-wha Univ.

• Jae-Moon Kim · Chungnam Univ.

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

16 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2008-03-31

Primary Completion

2012-05-31

Completion

2012-05-31

Countries

• South Korea

Study Locations