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Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections

NCT00801099 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 276

Last updated 2015-08-07

Study results available
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Summary

In a rural hospital in Tanzania the rate of surgical site infections (SSI) was 21.6%. Inappropriate choice of antibiotics and of administration time were determined as sole risk factors in this setting. After implementation of a standardized procedure with a single shot dose of Amoxicillin/Clavulanic Acid approximately 30 min. preoperatively the rate of SSI dropped by 80% in spite of procedural risk factors like poor hygiene etc.

Conditions

  • Surgical Site Infection

Interventions

DRUG

Amoxicillin/Clavulanic Acid

single shot dose of Amoxicillin/Clavulanic Acid approximately 30 min. preoperatively

Sponsors & Collaborators

  • Swiss Academy of Medical Sciences (SAMS)

    collaborator OTHER

  • Swiss Tropical & Public Health Institute

    lead OTHER

Principal Investigators

  • Christioph F Hatz, MD · Swiss Tropical & Public Health Institute

Study Design

Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
15 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-12-31
Primary Completion
2005-03-31
Completion
2005-03-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00801099 on ClinicalTrials.gov