Saving Residual Renal Function Among Haemodialysis Patients Receiving Irbesartan

Summary

Angiotensin II receptor blockers (ARB) are known to preserve kidney function among patients with kidney diseases and reduced renal function, but not among haemodialysis patients.

Haemodialysis patients often lose residual renal function after initiating dialysis leading to worsened quality of life, increased morbidity and mortality.

In this study an ARB is investigated in a double blind, randomised, parallel group, placebo controlled manner to see, if this ARB can save residual renal function among haemodialysis patients. Potential cardiovascular benefits of the treatment are also addressed.

Conditions

• Kidney Failure, Chronic

Interventions

DRUG

Irbesartan

Tablets, 300 mg \* 1 daily, 1 year

DRUG

Placebo matching irbesartan 150 mg

Tablets, 300 mg \* 1 daily, 1 year

Sponsors & Collaborators

• University of Aarhus

  lead OTHER

Principal Investigators

• Bente Jespersen, MD, DrMedSc · Department of Nephrology, Aarhus University Hospital, Skejby, Denmark

• Erik Sloth, MD, DrMedSc · Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Skejby, Denmark

• Jens Kristian D Jensen, MD, PhD · Department of Nephrology, Aarhus University Hospital, Skejby, Denmark

• Krista D Kjærgaard, MD, PhD · Department of Nephrology, Aarhus University Hospital, Skejby, Denmark

• Christian D Peters, MD · Department of Nephrology, Aarhus University Hospital, Skejby, Denmark

• Charlotte Strandhave, MD · Department of Nephrology, Aalborg University Hospital, Denmark

• Ida N Tietze, MD, PhD · Department of Internal Medicine, Region Hospital Viborg, Denmark

• Marija K Novosel, MD · Department of Internal Medicine, Region Hospital Fredericia, Denmark

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-04-30

Primary Completion

2013-01-31

Completion

2013-01-31

Countries

• Denmark

Study Locations