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Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation

NCT00779792 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2008-10-24

No results posted yet for this study

Summary

The purpose of this study is to compare the efficacy of glycerol ointment, triamcinolone acetonide ointment, clobetasol ointment and tacrolimus ointment on irritated skin in a cumulative skin irritation test model using healthy volunteers.

Conditions

  • Dermatitis, Contact
  • Dermatitis, Occupational

Interventions

DRUG

clobetasol

0.5 mg Clobetasol propionate (0.5 mg/g) ointment applied twice daily for 10 consecutive days

DRUG

triamcinolone acetonide

0.5 mg ointment twice daily for 10 consecutive days

DRUG

tacrolimus

0.5 mg tacrolimus ointment(0.1%) twice daily for 10 consecutive days

DRUG

glycerol

0.5 mg glycerol ointment (20%) twice daily for 10 consecutive days

DRUG

vehicle ointment (paraffin oil/soft white paraffin)

0.5 mg vehicle ointment twice daily for 10 consecutive days

Sponsors & Collaborators

  • LEO Pharma

    collaborator INDUSTRY

  • University of Southern Denmark

    collaborator OTHER

  • Odense University Hospital

    lead OTHER

Principal Investigators

  • Anders Clemmensen, MD · Department of Dermatology, Odense University Hospital

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
TRIPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-09-30
Primary Completion
2008-11-30
Completion
2008-11-30

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00779792 on ClinicalTrials.gov