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Drug Interaction Study of Rifampin and Warfarin in Healthy Volunteers.

NCT00777855 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2013-07-17

Study results available
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Summary

The purpose of this study is to determine the importance of uptake drug transporters in the drug disposition of warfarin. We predict that the elimination of warfarin will be decreased when co-dosed with an inhibitor of uptake drug transporters.

Conditions

  • Healthy

Interventions

DRUG

warfarin plus rifampin

warfarin 7.5mg po x 1; rifampin 600mg IV x 1

DRUG

warfarin

warfarin 7.5mg po x 1

Sponsors & Collaborators

Principal Investigators

  • Leslie Z Benet, PhD · University of California, San Francisco

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-11-30
Primary Completion
2009-03-31
Completion
2009-03-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00777855 on ClinicalTrials.gov