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Circulating Adenosine Levels Before and After Intravenous (IV) Persantine

NCT00760708 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 221

Last updated 2019-05-14

No results posted yet for this study

Summary

Persantine is a drug that is routinely used to determine blood flow to the heart in the diagnosis of coronary heart disease. Persantine causes an increase in the adenosine level in the blood. Adenosine is a naturally occurring substance in the body that can increase blood flow. Adenosine is normally removed from the bloodstream by an adenosine transporter, which is a protein that takes up adenosine from the blood into cells. The increase in adenosine levels in the blood is variable, and the cause for this variability is unknown. A mutation for this transporter gene may contribute to this variability, and may alter its function. Thus, the purpose of this study is to determine the relationship between the mutation and the transporter function.

Conditions

  • Ischemia
  • Coronary Disease

Sponsors & Collaborators

  • United States Department of Defense

    collaborator FED

  • UConn Health

    lead OTHER

Principal Investigators

  • Bruce T Liang, MD · UConn Health

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-09-30
Primary Completion
2011-12-31
Completion
2011-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00760708 on ClinicalTrials.gov