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Transfusing Neonates Based on Platelet Mass

NCT00759980 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2011-03-23

No results posted yet for this study

Summary

Thrombocytopenia (low platelet count) is common in the neonatal intensive care unit. Commonly, the decision of when to transfuse platelets is based on platelet number. Recently, Christensen et al (2006) proposed using transfusion guidelines based on platelet mass rather than platelet number. By using platelet size as a guide of when to give platelets, we may be able to decrease the amount platelet transfusions needed.

This study is investigating using platelet size rather than platelet number as a guideline for transfusing platelets in infants who are hospitalized in a NICU (neonatal intensive care unit). After obtaining parental informed consent, thrombocytopenic infants will be randomized to one of two groups. 1: Transfusion based on platelet number; 2: transfusion based on a combination of platelet number and platelet mass. In each group the decision to transfuse platelets will be made using a slightly different, yet strict set of transfusion rules.

The objective is to determine the feasibility, rate of bleeding complications and compliance of transfusing neonates based on platelet mass rather than platelet number.

The investigators hypothesize that transfusing platelets based on platelet mass will not increase bleeding complications and will reduce the number of transfusions in thrombocytopenic neonates.

Conditions

Sponsors & Collaborators

  • Alfred I. duPont Hospital for Children

    collaborator OTHER

  • Thomas Jefferson University

    collaborator OTHER

  • Abington Memorial Hospital

    collaborator OTHER

  • Christiana Care Health Services

    lead OTHER

Principal Investigators

  • Jody L Zisk, DO · Christiana Care Health Services

  • David A Paul, MD · Christiana Care Health Systems

Eligibility

Max Age
12 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-10-31
Primary Completion
2011-03-31
Completion
2011-03-31

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00759980 on ClinicalTrials.gov