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Cerebral Perfusion, Oxygenation, Electrical Activity

NCT00747682 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2010-06-24

No results posted yet for this study

Summary

The specific aim of the research proposal in preterm infants with IVH and PHH who require placement of an Omaya reservoir or a shunt is to determine if decreasing ventricular volume improves, middle cerebral artery flow, cerebral oxygenation, and cortical neuronal electrical activity. To accomplish this aim, we will simultaneously perform the following evaluations prior to shunt placement or prior to and after routine CSF aspiration from reservoir in:

1. middle cerebral artery velocity time integral and resistive index using Doppler ultrasonography
2. cerebral oxygenation using near infrared spectroscopy (NIRS)
3. background neuronal electrical activity using an EEG. In addition, we will measure serial CSF concentration of neuroproteins, S100B, GFAP, NSE, TGF-ß, and IL-6, as evidence of ongoing neuronal damage and correlate the concentration with cerebral perfusion and activity as measured above.

Conditions

  • Post-Hemorrhagic Hydrocephalus

Sponsors & Collaborators

Principal Investigators

  • Joanna Beachy, M.D. · University of Utah

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-07-31
Primary Completion
2009-05-31
Completion
2009-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00747682 on ClinicalTrials.gov