A Phase 1 Dose Escalation Study of IPI-493
NCT00724425 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 53
Last updated 2015-04-15
Summary
IPI-493 is a potent inhibitor of heat shock protein 90 (Hsp90) and is orally bioavailable via a novel formulation.
Conditions
- Advanced Malignancies
Interventions
- DRUG
-
IPI-493
Capsules, Multiple Schedules
Sponsors & Collaborators
-
Infinity Pharmaceuticals, Inc.
lead INDUSTRY
Principal Investigators
-
Robert Ross, MD · Infinity Pharmaceuticals, Inc.
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-07-31
- Primary Completion
- 2011-07-31
- Completion
- 2011-07-31
Countries
- United States
Study Locations
More Related Trials
-
Study Evaluating the Efficacy and Safety of IPI 504 in Patients With Advanced Dedifferentiated Liposarcoma
NCT00969917 ·Status: WITHDRAWN ·Phase: PHASE2
-
Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors
NCT03634982 ·Status: UNKNOWN ·Phase: PHASE1
-
A Dose-escalation Study in Subjects With Advanced Malignancies
NCT01195311 ·Status: COMPLETED ·Phase: PHASE1
-
A Study Exploring the Safety and Tolerability of INCB081776 in Participants With Advanced Malignancies
NCT03522142 ·Status: TERMINATED ·Phase: PHASE1
-
Phase 1 Study of BPI-442096 in Advanced Solid Tumor Patients
NCT05369312 ·Status: UNKNOWN ·Phase: PHASE1
-
Study of ICP-105 in Solid Tumors Patients
NCT03642834 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors
NCT04272034 ·Status: TERMINATED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors
NCT04242199 ·Status: COMPLETED ·Phase: PHASE1
-
Ph. 1, Evaluation of Safety, Tolerability, PK, Anti-tumor Activity of STP707 IV in Subjects With Solid Tumors
NCT05037149 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Phase I Study of CPI-300 in Patients With Advanced Tumors
NCT04808453 ·Status: COMPLETED ·Phase: PHASE1
-
To Assess the Safety, Tolerability and Pharmacokinetics of INCB086550
NCT04674748 ·Status: TERMINATED ·Phase: PHASE1
-
Study Of Anti-IGF-IR CP-751,871 In Patients With Solid Tumors
NCT00474760 ·Status: COMPLETED ·Phase: PHASE1
-
Extended Administration of Polyethylene Glycol (PEG) Interferon Alfa-2b in Participants With Solid Tumors (C/I97-349/MK-4031-009)
NCT03554005 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase Ia/ Ib Study of HS387 in Subjects With Advanced Solid Tumors
NCT07092748 ·Status: RECRUITING ·Phase: PHASE1
-
A Study Exploring the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB086550 in Participants With Advanced Solid Tumors
NCT03762447 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Study of Oral Ixabepilone in Subjects With Advanced Cancer
NCT00422097 ·Status: COMPLETED ·Phase: PHASE1
-
Phase 1/2, Open-label, Dose-escalation Study of IONIS-STAT3Rx, Administered to Patients With Advanced Cancers
NCT01563302 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
An Open-Label, Dose-Escalation Study of INCB054329 in Patients With Advanced Malignancies
NCT02431260 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of DSP-0509 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic Profile
NCT03416335 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of Dose Escalation of IBI321 in Patients With Advanced Solid Tumors
NCT04911894 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors
NCT01892046 ·Status: COMPLETED ·Phase: PHASE1
-
Phase 1/1b Dose Escalation Study Evaluating BSI-201 as a Single Agent and in Combination With Irinotecan in Subjects With Advanced Solid Tumors
NCT00298675 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Irinotecan Hydrochloride Liposome in Combination With 5-FU/LV in Advanced Solid Tumors
NCT05086848 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of the Safety and Tolerability of IBI321 in Patients With Advanced Solid Tumors
NCT04911881 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1, Open-label, Multicenter, Dose Escalation Study of IBI363 (PD1-IL2m) in Subjects With Advanced Solid Malignancies or Lymphomas
NCT05290597 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1