Trial Outcomes & Findings for Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI) (NCT NCT00714571)

Results Overview

Accuracy (Percent correct) for trained stimuli. Stage 1: Object location association test Stage 2: Face name association test

Recruitment status

COMPLETED

Study phase

PHASE1

Target enrollment

82 participants

Primary outcome timeframe

Pre-training, post-training, 1 month

Results posted on

2017-01-04

Participant Flow

Participant milestones

Participant milestones
Measure	MST Healthy Older Adults: Stage 1 Mnemonic strategy training for object location associations for healthy older adults	MST MCI: Stage 1 Mnemonic strategy training for object location associations in patients with MCI	XP Healthy Older Adults: Stage 1 Repeated exposure for object location associations in healthy older adults	XP MCI: Stage 1 Repeated exposure for object location associations in patients with MCI	MST Healthy Older Adults: Stage 2 Mnemonic strategy training for face name associations in healthy older adults	SCT Healthy Older Adults: Stage 2 Subtracting cues training for face name associations in healthy older adults
Stage 2 STARTED	0	0	0	0	15	15
Stage 1 STARTED	12	15	11	14	0	0
Stage 1 COMPLETED	12	15	10	14	0	0
Stage 1 NOT COMPLETED	0	0	1	0	0	0
Stage 2 COMPLETED	0	0	0	0	15	15
Stage 2 NOT COMPLETED	0	0	0	0	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	MST Healthy Older Adults: Stage 1 n=11 Participants Mnemonic strategy training for object location associations for healthy older adults	MST MCI: Stage 1 n=14 Participants Mnemonic strategy training for object location associations in patients with MCI	XP Healthy Older Adults: Stage 1 n=10 Participants Repeated exposure for object location associations in healthy older adults	XP MCI: Stage 1 n=14 Participants Repeated exposure for object location associations in patients with MCI	MST Healthy Older Adults: Stage 2 n=15 Participants Mnemonic strategy training for face name associations in healthy older adults	SCT Healthy Older Adults: Stage 2 n=15 Participants Subtracting cues training for face name associations in healthy older adults	Total n=79 Participants Total of all reporting groups
Age, Continuous	73.2 years STANDARD_DEVIATION 7.7 • n=99 Participants	73.5 years STANDARD_DEVIATION 10.1 • n=107 Participants	72.5 years STANDARD_DEVIATION 6.8 • n=206 Participants	70.5 years STANDARD_DEVIATION 5.8 • n=7 Participants	67.1 years STANDARD_DEVIATION 7.9 • n=31 Participants	72.0 years STANDARD_DEVIATION 7.6 • n=30 Participants	71.3 years STANDARD_DEVIATION 7.9 • n=3 Participants
Gender Female	7 Participants n=99 Participants	4 Participants n=107 Participants	6 Participants n=206 Participants	8 Participants n=7 Participants	13 Participants n=31 Participants	13 Participants n=30 Participants	51 Participants n=3 Participants
Gender Male	4 Participants n=99 Participants	10 Participants n=107 Participants	4 Participants n=206 Participants	6 Participants n=7 Participants	2 Participants n=31 Participants	2 Participants n=30 Participants	28 Participants n=3 Participants
Region of Enrollment United States	11 participants n=99 Participants	14 participants n=107 Participants	10 participants n=206 Participants	14 participants n=7 Participants	15 participants n=31 Participants	15 participants n=30 Participants	79 participants n=3 Participants

PRIMARY outcome

Timeframe: Pre-training, post-training, 1 month

Population: MST older adults Stage 1: 1 participant excluded due to undisclosed ongoing chemotherapy treatment XP older adults Stage 1: 1 participant decided not to participate after randomization MST MCI Stage 1: 1 participant diagnosed with Alzheimer's dementia within 1 month of completing study

Accuracy (Percent correct) for trained stimuli. Stage 1: Object location association test Stage 2: Face name association test