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Circadian Variations in Ocular Blood Flow in Glaucomatous and Normal Eyes

NCT00707226 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2008-06-30

No results posted yet for this study

Summary

After focusing many years only on intraocular pressure (IOP) as the primary risk factor, recently the impact of ocular blood flow is getting more consideration for the pathophysiology of glaucoma. The circadian change of intraocular pressure (IOP) is well investigated, but diurnal variations in ocular blood flow are yet to be evaluated, especially in glaucomatous eyes.

This study is performed to investigate circadian variation of ocular blood flow assessed by laser interferometric fundus pulsation amplitude (FPA) and laser Doppler flowmetry (LDF) in glaucomatous eyes during topical antiglaucoma therapy at 8:00, 12:00, 17:00 and 21:00, to compare these circadian variation of ocular blood flow in glaucomatous eyes with variations in healthy eyes and to relate blood flow variations with IOP variations.

Conditions

  • Glaucoma, Open-Angle
  • Circadian Rhythm
  • Intraocular Pressure
  • Regional Blood Flow

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Michael Georgopoulos, MD · Department of Clinical Ophthalmology, Medical University of Vienna

Eligibility

Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2000-11-30
Completion
2001-12-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00707226 on ClinicalTrials.gov