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Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery

NCT00699946 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 495

Last updated 2009-01-21

No results posted yet for this study

Summary

In this study we wanted to determine if perioperative administration of olanzapine prior to knee or hip replacement surgery in high risk patients would prevent the onset of postoperative delirium.

Conditions

  • Delirium

Interventions

DRUG

olanzapine

5 mg preoperative and 5mg postoperative prior to discharge to inpatient nursing floor

DRUG

placebo

placebo administered preoperatively and postoperatively prior to discharge to inpatient nursing floor

Sponsors & Collaborators

  • The New England Baptist Hospital

    lead OTHER

Principal Investigators

  • Susan Kelly, MD · New England Baptist Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-01-31
Primary Completion
2007-08-31
Completion
2007-10-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00699946 on ClinicalTrials.gov