Decitabine, Arsenic Trioxide and Ascorbic Acid for Myelodysplastic Syndromes and Acute Myeloid Leukemia
NCT00671697 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 13
Last updated 2013-06-04
Summary
This study is designed to test the combination of decitabine, arsenic trioxide and ascorbic acid in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia
Conditions
- Myelodysplastic Syndromes and Leukemia, Myeloid, Acute
Interventions
- DRUG
-
Arsenic Trioxide
- DRUG
-
Decitabine
Sponsors & Collaborators
-
Cephalon
collaborator INDUSTRY -
Washington University School of Medicine
lead OTHER
Principal Investigators
-
Ravi Vij, M.D. · Washington Univerisity
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-05-31
- Primary Completion
- 2010-01-31
- Completion
- 2011-05-31
Countries
- United States
Study Locations
More Related Trials
-
Arsenic Trioxide in Treating Patients With Acute Myeloid Leukemia
NCT00005795 ·Status: COMPLETED ·Phase: PHASE2
-
Arsenic Trioxide in Combination With Cytarabine in Patients With High-risk MDS and Poor-prognosis AML
NCT00195104 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Mutant p53-based Personalized Trial Using Decitabine and Arsenic Trioxide on AML/MDS
NCT03855371 ·Status: UNKNOWN ·Phase: PHASE1
-
Arsenic Trioxide in Treating Patients With Refractory or Recurrent Acute Promyelocytic Leukemia
NCT00008697 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of Oral Tetrahydrouridine-Decitabine in Relapsed or Refractory Myelodysplastic Syndromes (MDS)
NCT07006025 ·Status: RECRUITING ·Phase: PHASE1
-
Decitabine and Gemtuzumab Ozogamicin in Acute Myelogenous Leukemia and High-risk Myelodysplastic Syndrome
NCT00968071 ·Status: COMPLETED ·Phase: PHASE2
-
Azacitidine and Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia
NCT00118196 ·Status: TERMINATED ·Phase: PHASE2
-
Decitabine,Cytarabine and Arsenic Trioxide for Acute Myeloid Leukemia With p53 Mutations
NCT03381781 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of ASTX727 vs IV Decitabine in Participants With MDS, CMML, and AML
NCT03306264 ·Status: COMPLETED ·Phase: PHASE3
-
Decitabine Maintenance for Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS) Post Transplant
NCT00986804 ·Status: COMPLETED ·Phase: PHASE1
-
Decitabine Versus Azacitidine in Myelodysplastic Syndrome Patients With Low and Intermediate-1 Risk
NCT01720225 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Research Study of Arsenic Trioxide (Trisenox) in Patients With Myelodysplastic Syndrome (MDS)
NCT00225992 ·Status: TERMINATED ·Phase: PHASE2
-
Use of Decitabine in Myelodysplastic Syndrome (MDS) Following Azacitidine (AZA) Failure
NCT01133886 ·Status: UNKNOWN ·Phase: PHASE2
-
Decitabine, Cytarabine, and Daunorubicin Hydrochloride in Treating Patients With Acute Myeloid Leukemia
NCT01627041 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Decitabine With GCLAM for Adults With Newly Diagnosed, Relapsed, or Refractory AML or High-Risk MDS
NCT02921061 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Arsenic Trioxide, Cytarabine, and Idarubicin in Treating Patients With Acute Myeloid Leukemia
NCT00093483 ·Status: COMPLETED ·Phase: PHASE1
-
Decitabine and Cytarabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia, High Risk Myelodysplastic Syndrome, or Myeloproliferative Neoplasm
NCT02121418 ·Status: COMPLETED ·Phase: NA
-
Decitabine Followed by Mitoxantrone Hydrochloride, Etoposide, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes
NCT01729845 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
High-dose Ascorbate (HDA) in Combination With Standard of Care Azacitidine and Venetoclax in Acute Myeloid Leukemia (AML)
NCT07177079 ·Status: RECRUITING ·Phase: PHASE1
-
TET2 Mutations in Myelodysplastic Syndromes and Acute Myeloid Leukemia With Azacitidine + Ascorbic Acid
NCT03397173 ·Status: COMPLETED ·Phase: PHASE2
-
Azacytidine With Valproic Acid Versus Ara-C in Acute Myeloid Leukemia (AML)/ Myelodysplastic Syndrome (MDS) Patients
NCT00382590 ·Status: COMPLETED ·Phase: PHASE2
-
Tretinoin, Cytarabine, and Daunorubicin Hydrochloride With or Without Arsenic Trioxide Followed by Tretinoin With or Without Mercaptopurine and Methotrexate in Treating Patients With Acute Promyelocytic Leukemia
NCT00003934 ·Status: COMPLETED ·Phase: PHASE3
-
S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
NCT00109837 ·Status: COMPLETED ·Phase: PHASE2
-
Arsenic Trioxide for Induction Therapy of Adult Patients With Leukemia
NCT00006092 ·Status: TERMINATED ·Phase: PHASE2
-
Study of PDR001 and/or MBG453 in Combination With Decitabine in Patients With AML or High Risk MDS
NCT03066648 ·Status: COMPLETED ·Phase: PHASE1