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Immunoregulation by Controlled Parasite Exposure in Multiple Sclerosis.

NCT00630383 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL

Last updated 2012-06-14

No results posted yet for this study

Summary

The aim of the study is to determine whether controlled infection with a clinically safe number of larvae of hookworm results in an immune response that is protective in relapsing MS.

Conditions

Interventions

BIOLOGICAL

Live Hookworm Larvae

25 live hookworm will be applied to the arm and will infect transdermally. They will be eradicated after 48 weeks.

OTHER

Histamine

0.01% histamine solution is pipetted onto a plaster dressing.

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Cris Constantinescu, MD PhD · University of Nottingham

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-02-29
Primary Completion
2008-05-31
Completion
2008-05-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00630383 on ClinicalTrials.gov