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The Effect on Cognition of Terminating ECT Induced Seizures With Propofol

NCT00616759 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2021-06-08

Study results available
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Summary

Participating subjects are those who are referred for electroconvulsive therapy (ECT) for severe depression who have agreed to the protocol. The control group receives ECT as usual. The other group receives propofol to terminate the ECT-induced seizure timed so that the seizure lasts at least 25 seconds. Extensive neuropsychological testing is being done on both groups before beginning ECT and within 48 hours after the 6th treatment. Multiple markers of the rapidity of recovery from anesthesia are being obtained from all subjects for 6 ECTs.

Conditions

Interventions

PROCEDURE

electroconvulsive therapy

electroconvulsive therapy as usual

PROCEDURE

electroconvulsive therapy plus propofol

electroconvulsive therapy identical to the comparator group except that propofol 0.5 mg/kg is given intravenously 15 seconds after the electrical stimulation at each treatment in order to terminate the ECT-induced seizure

DRUG

propofol

Propofol 0.5 mg/kg intravenously given 15 seconds following electrical stimulation

Sponsors & Collaborators

  • Loma Linda University

    lead OTHER

Principal Investigators

  • Ronald L Warnell, MD · Loma Linda University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-09-30
Primary Completion
2010-03-24
Completion
2010-03-24

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00616759 on ClinicalTrials.gov