Trial Outcomes & Findings for GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence (NCT NCT00611767)
NCT ID: NCT00611767
Last Updated: 2017-03-17
Results Overview
Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
COMPLETED
NA
73 participants
Baseline
2017-03-17
Participant Flow
Participant milestones
| Measure |
Family History Negative for Alcoholism
Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). No family history of alcoholism in any first or second-degree relatives.
|
Family History Positive for Alcoholism
Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). Biological father and another first or second-degree biological relative with a history of alcoholism by Family History Assessment Module (FHAM) developed by The Collaborative Study on the Genetics of Alcoholism (COGA).
|
|---|---|---|
|
Overall Study
STARTED
|
49
|
24
|
|
Overall Study
Thiopental Test Day
|
3
|
1
|
|
Overall Study
Placebo Test Day
|
6
|
1
|
|
Overall Study
COMPLETED
|
40
|
22
|
|
Overall Study
NOT COMPLETED
|
9
|
2
|
Reasons for withdrawal
| Measure |
Family History Negative for Alcoholism
Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). No family history of alcoholism in any first or second-degree relatives.
|
Family History Positive for Alcoholism
Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). Biological father and another first or second-degree biological relative with a history of alcoholism by Family History Assessment Module (FHAM) developed by The Collaborative Study on the Genetics of Alcoholism (COGA).
|
|---|---|---|
|
Overall Study
Withdrawal by Subject
|
4
|
1
|
|
Overall Study
Thiopental not available
|
3
|
0
|
|
Overall Study
didn't like the medication
|
1
|
1
|
|
Overall Study
Physician Decision
|
1
|
0
|
Baseline Characteristics
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
Baseline characteristics by cohort
| Measure |
Family History Negative for Alcoholism
n=49 Participants
Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). No family history of alcoholism in any first or second-degree relatives.
|
Family History Positive for Alcoholism
n=24 Participants
Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). Biological father and another first or second-degree biological relative with a history of alcoholism by Family History Assessment Module (FHAM) developed by COGA.
|
Total
n=73 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=39 Participants
|
0 Participants
n=41 Participants
|
0 Participants
n=35 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
49 Participants
n=39 Participants
|
24 Participants
n=41 Participants
|
73 Participants
n=35 Participants
|
|
Age, Categorical
>=65 years
|
0 Participants
n=39 Participants
|
0 Participants
n=41 Participants
|
0 Participants
n=35 Participants
|
|
Age, Continuous
|
24.02 years
STANDARD_DEVIATION 2.5 • n=39 Participants
|
24.63 years
STANDARD_DEVIATION 3.06 • n=41 Participants
|
24.22 years
STANDARD_DEVIATION 2.69 • n=35 Participants
|
|
Sex: Female, Male
Female
|
25 Participants
n=39 Participants
|
10 Participants
n=41 Participants
|
35 Participants
n=35 Participants
|
|
Sex: Female, Male
Male
|
24 Participants
n=39 Participants
|
14 Participants
n=41 Participants
|
38 Participants
n=35 Participants
|
|
Region of Enrollment
United States
|
49 participants
n=39 Participants
|
24 participants
n=41 Participants
|
73 participants
n=35 Participants
|
PRIMARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales of Similarity to Alcohol - Baseline
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales of Similarity to Alcohol - Baseline
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
PRIMARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales of Similarity to Alcohol - 15 Minutes
Thiopental
|
3.23 units on a scale
Standard Deviation 2.08
|
2.35 units on a scale
Standard Deviation 1.90
|
|
Visual Analog Scales of Similarity to Alcohol - 15 Minutes
Placebo
|
0.04 units on a scale
Standard Deviation 0.30
|
0.17 units on a scale
Standard Deviation 0.65
|
PRIMARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models.
Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales of Similarity to Alcohol - 45 Minutes
Thiopental
|
2.91 units on a scale
Standard Deviation 1.97
|
1.87 units on a scale
Standard Deviation 1.71
|
|
Visual Analog Scales of Similarity to Alcohol - 45 Minutes
Placebo
|
0.04 units on a scale
Standard Deviation 0.21
|
0.04 units on a scale
Standard Deviation 0.21
|
PRIMARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales of Similarity to Alcohol - 80 Minutes
Thiopental
|
0.84 units on a scale
Standard Deviation 1.33
|
0.50 units on a scale
Standard Deviation 0.74
|
|
Visual Analog Scales of Similarity to Alcohol - 80 Minutes
Placebo
|
0.04 units on a scale
Standard Deviation 0.30
|
0 units on a scale
Standard Deviation 0
|
PRIMARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales of Similarity to Alcohol - 110 Minutes
Thiopental
|
0.35 units on a scale
Standard Deviation 0.92
|
0.22 units on a scale
Standard Deviation 0.85
|
|
Visual Analog Scales of Similarity to Alcohol - 110 Minutes
Placebo
|
0.11 units on a scale
Standard Deviation 0.74
|
0 units on a scale
Standard Deviation 0
|
PRIMARY outcome
Timeframe: 170 minutesPopulation: All available data was utilized in the analysis using mixed models.
Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales of Similarity to Alcohol - 170 Minutes
Thiopental
|
0.02 units on a scale
Standard Deviation 0.15
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales of Similarity to Alcohol - 170 Minutes
Placebo
|
0.02 units on a scale
Standard Deviation 0.15
|
0 units on a scale
Standard Deviation 0
|
PRIMARY outcome
Timeframe: 230 minutesPopulation: All available data was utilized in the analysis using mixed models.
Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales of Similarity to Alcohol - 230 Minutes
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales of Similarity to Alcohol - 230 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Number of Drinks Felt Consumed at Baseline
Thiopental
|
0 number of drinks felt consumed
Standard Deviation 0
|
0 number of drinks felt consumed
Standard Deviation 0
|
|
Number of Drinks Felt Consumed at Baseline
Placebo
|
0 number of drinks felt consumed
Standard Deviation 0
|
0 number of drinks felt consumed
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Number of Drinks Felt Consumed - 15 Minutes
Thiopental
|
3.28 number of drinks felt consumed
Standard Deviation 2.10
|
3.22 number of drinks felt consumed
Standard Deviation 2.63
|
|
Number of Drinks Felt Consumed - 15 Minutes
Placebo
|
0.11 number of drinks felt consumed
Standard Deviation 0.43
|
0.17 number of drinks felt consumed
Standard Deviation 0.49
|
SECONDARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models.
The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Number of Drinks Felt Consumed - 45 Minutes
Thiopental
|
3 number of drinks felt consumed
Standard Deviation 2
|
2.91 number of drinks felt consumed
Standard Deviation 2.67
|
|
Number of Drinks Felt Consumed - 45 Minutes
Placebo
|
0.03 number of drinks felt consumed
Standard Deviation 0.16
|
0.04 number of drinks felt consumed
Standard Deviation 0.21
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Number of Drinks Felt Consumed - 80 Minutes
Thiopental
|
1.14 number of drinks felt consumed
Standard Deviation 1.78
|
0.96 number of drinks felt consumed
Standard Deviation 1.15
|
|
Number of Drinks Felt Consumed - 80 Minutes
Placebo
|
0.04 number of drinks felt consumed
Standard Deviation 0.30
|
0 number of drinks felt consumed
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Number of Drinks Felt Consumed - 110 Minutes
Thiopental
|
0.35 number of drinks felt consumed
Standard Deviation 0.92
|
0.22 number of drinks felt consumed
Standard Deviation 0.6
|
|
Number of Drinks Felt Consumed - 110 Minutes
Placebo
|
0.04 number of drinks felt consumed
Standard Deviation 0.30
|
0 number of drinks felt consumed
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 170 minutesPopulation: All available data was utilized in the analysis using mixed models.
The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Number of Drinks Felt Consumed - 170 Minutes
Thiopental
|
0 number of drinks felt consumed
Standard Deviation 0
|
0 number of drinks felt consumed
Standard Deviation 0
|
|
Number of Drinks Felt Consumed - 170 Minutes
Placebo
|
0.02 number of drinks felt consumed
Standard Deviation 0.15
|
0 number of drinks felt consumed
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 230 minutesPopulation: All available data was utilized in the analysis using mixed models.
The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Number of Drinks Felt Consumed - 230 Minutes
Thiopental
|
0 number of drinks felt consumed
Standard Deviation 0
|
0 number of drinks felt consumed
Standard Deviation 0
|
|
Number of Drinks Felt Consumed - 230 Minutes
Placebo
|
0 number of drinks felt consumed
Standard Deviation 0
|
0 number of drinks felt consumed
Standard Deviation 0
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline
Thiopental
|
1.86 units on a scale
Standard Deviation 4.41
|
1.22 units on a scale
Standard Deviation 3.67
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline
Placebo
|
2.74 units on a scale
Standard Deviation 7.16
|
1.91 units on a scale
Standard Deviation 5.73
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes
Thiopental
|
5.26 units on a scale
Standard Deviation 9.38
|
3.87 units on a scale
Standard Deviation 6.24
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes
Placebo
|
1.5 units on a scale
Standard Deviation 3.97
|
1.87 units on a scale
Standard Deviation 4.46
|
SECONDARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes
Thiopental
|
2.33 units on a scale
Standard Deviation 4.07
|
2.70 units on a scale
Standard Deviation 4.99
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes
Placebo
|
1.13 units on a scale
Standard Deviation 3.21
|
1.57 units on a scale
Standard Deviation 3.72
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes
Thiopental
|
1.37 units on a scale
Standard Deviation 2.82
|
1.78 units on a scale
Standard Deviation 4.38
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes
Placebo
|
1.5 units on a scale
Standard Deviation 4.21
|
1.35 units on a scale
Standard Deviation 3.33
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes
Thiopental
|
1.12 units on a scale
Standard Deviation 2.22
|
1.52 units on a scale
Standard Deviation 3.94
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes
Placebo
|
1.44 units on a scale
Standard Deviation 4.38
|
1.91 units on a scale
Standard Deviation 4.80
|
SECONDARY outcome
Timeframe: 170 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes
Thiopental
|
0.98 units on a scale
Standard Deviation 2.33
|
1.39 units on a scale
Standard Deviation 3.73
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes
Placebo
|
1.85 units on a scale
Standard Deviation 6.16
|
1.65 units on a scale
Standard Deviation 4.00
|
SECONDARY outcome
Timeframe: 230 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes
Thiopental
|
1 units on a scale
Standard Deviation 2.01
|
2.30 units on a scale
Standard Deviation 6.32
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes
Placebo
|
1.72 units on a scale
Standard Deviation 4.70
|
2.04 units on a scale
Standard Deviation 5.17
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline
Thiopental
|
1.49 units on a scale
Standard Deviation 2.55
|
0.48 units on a scale
Standard Deviation 0.95
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline
Placebo
|
1.20 units on a scale
Standard Deviation 2.52
|
0.44 units on a scale
Standard Deviation 1.31
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models
Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes
Thiopental
|
16.07 units on a scale
Standard Deviation 17.75
|
6.74 units on a scale
Standard Deviation 8.30
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes
Placebo
|
1.41 units on a scale
Standard Deviation 3.29
|
2.04 units on a scale
Standard Deviation 6.87
|
SECONDARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes
Thiopental
|
15.83 units on a scale
Standard Deviation 13.79
|
9.30 units on a scale
Standard Deviation 12.10
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes
Placebo
|
1.70 units on a scale
Standard Deviation 4.61
|
1.17 units on a scale
Standard Deviation 3.94
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes
Thiopental
|
7.98 units on a scale
Standard Deviation 10.34
|
3.48 units on a scale
Standard Deviation 6.07
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes
Placebo
|
0.94 units on a scale
Standard Deviation 2.27
|
0.74 units on a scale
Standard Deviation 2.34
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes
Thiopental
|
2.37 units on a scale
Standard Deviation 4.34
|
1.61 units on a scale
Standard Deviation 4.33
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes
Placebo
|
0.63 units on a scale
Standard Deviation 1.88
|
0.78 units on a scale
Standard Deviation 2.59
|
SECONDARY outcome
Timeframe: 170 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes
Thiopental
|
0.83 units on a scale
Standard Deviation 1.87
|
0.52 units on a scale
Standard Deviation 1.90
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes
Placebo
|
0.26 units on a scale
Standard Deviation 0.74
|
0.44 units on a scale
Standard Deviation 1.16
|
SECONDARY outcome
Timeframe: 230 minutesPopulation: All available data was utilized in the analysis using mixed models.
Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes
Thiopental
|
0.45 units on a scale
Standard Deviation 1.33
|
0.22 units on a scale
Standard Deviation 0.85
|
|
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes
Placebo
|
0.15 units on a scale
Standard Deviation 0.52
|
0.26 units on a scale
Standard Deviation 0.75
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - High - Baseline
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - High - Baseline
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - High - 15 Minutes
Thiopental
|
2.35 units on a scale
Standard Deviation 2.25
|
1.74 units on a scale
Standard Deviation 1.66
|
|
Visual Analog Scales (VAS) - High - 15 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models
visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - High - 45 Minutes
Thiopental
|
1.69 units on a scale
Standard Deviation 1.80
|
1.26 units on a scale
Standard Deviation 2.03
|
|
Visual Analog Scales (VAS) - High - 45 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models
visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - High - 80 Minutes
Thiopental
|
0.40 units on a scale
Standard Deviation 1.00
|
0.61 units on a scale
Standard Deviation 1.08
|
|
Visual Analog Scales (VAS) - High - 80 Minutes
Placebo
|
0.02 units on a scale
Standard Deviation 0.15
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models
visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - High - 110 Minutes
Thiopental
|
0.14 units on a scale
Standard Deviation 0.64
|
0.13 units on a scale
Standard Deviation 0.46
|
|
Visual Analog Scales (VAS) - High - 110 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 170 minutesPopulation: All available data was utilized in the analysis using mixed models
visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - High - 170 Minutes
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - High - 170 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 230 minutesPopulation: All available data was utilized in the analysis using mixed models
visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - High - 230 Minutes
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - High - 230 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models
visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Buzzed - Baseline
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Buzzed - Baseline
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models
visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Buzzed - 15 Minutes
Thiopental
|
2.07 units on a scale
Standard Deviation 2.06
|
1.65 units on a scale
Standard Deviation 1.85
|
|
Visual Analog Scales (VAS) - Buzzed - 15 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0.04 units on a scale
Standard Deviation 0.21
|
SECONDARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models
visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Buzzed - 45 Minutes
Thiopental
|
1.74 units on a scale
Standard Deviation 1.78
|
1.26 units on a scale
Standard Deviation 1.94
|
|
Visual Analog Scales (VAS) - Buzzed - 45 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0.04 units on a scale
Standard Deviation 0.21
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) .
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Buzzed - 80 Minutes
Placebo
|
0.04 units on a scale
Standard Deviation 0.30
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Buzzed - 80 Minutes
Thiopental
|
0.21 units on a scale
Standard Deviation 0.68
|
0.52 units on a scale
Standard Deviation 0.99
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Buzzed - 110 Minutes
Thiopental
|
0.02 units on a scale
Standard Deviation 0.15
|
0.13 units on a scale
Standard Deviation 0.46
|
|
Visual Analog Scales (VAS) - Buzzed - 110 Minutes
Placebo
|
0.02 units on a scale
Standard Deviation 0.15
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 170 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Buzzed - 170 Minutes
Thiopental
|
0.02 units on a scale
Standard Deviation 0.15
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Buzzed - 170 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 230 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Buzzed - 230 Minutes
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Buzzed - 230 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Drowsy - Baseline
Thiopental
|
0.61 units on a scale
Standard Deviation 1.05
|
0.52 units on a scale
Standard Deviation 1.04
|
|
Visual Analog Scales (VAS) - Drowsy - Baseline
Placebo
|
0.22 units on a scale
Standard Deviation 0.51
|
0.48 units on a scale
Standard Deviation 1.31
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Drowsy - 15 Minutes
Thiopental
|
2.86 units on a scale
Standard Deviation 2.48
|
1.74 units on a scale
Standard Deviation 1.86
|
|
Visual Analog Scales (VAS) - Drowsy - 15 Minutes
Placebo
|
0.39 units on a scale
Standard Deviation 0.71
|
0.35 units on a scale
Standard Deviation 0.57
|
SECONDARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) .
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Drowsy - 45 Minutes
Thiopental
|
3.02 units on a scale
Standard Deviation 2.44
|
2.74 units on a scale
Standard Deviation 2.01
|
|
Visual Analog Scales (VAS) - Drowsy - 45 Minutes
Placebo
|
0.44 units on a scale
Standard Deviation 0.91
|
0.39 units on a scale
Standard Deviation 0.58
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Drowsy - 80 Minutes
Thiopental
|
2.14 units on a scale
Standard Deviation 1.82
|
1.48 units on a scale
Standard Deviation 1.59
|
|
Visual Analog Scales (VAS) - Drowsy - 80 Minutes
Placebo
|
0.20 units on a scale
Standard Deviation 0.45
|
0.35 units on a scale
Standard Deviation 0.78
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Drowsy - 110 Minutes
Thiopental
|
1.19 units on a scale
Standard Deviation 1.64
|
1.13 units on a scale
Standard Deviation 1.25
|
|
Visual Analog Scales (VAS) - Drowsy - 110 Minutes
Placebo
|
0.13 units on a scale
Standard Deviation 0.4
|
0.30 units on a scale
Standard Deviation 0.70
|
SECONDARY outcome
Timeframe: 170 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Drowsy - 170 Minutes
Thiopental
|
0.38 units on a scale
Standard Deviation 0.66
|
0.26 units on a scale
Standard Deviation 0.54
|
|
Visual Analog Scales (VAS) - Drowsy - 170 Minutes
Placebo
|
0.15 units on a scale
Standard Deviation 0.56
|
0.22 units on a scale
Standard Deviation 0.60
|
SECONDARY outcome
Timeframe: 230 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Drowsy - 230 Minutes
Thiopental
|
0.31 units on a scale
Standard Deviation 0.60
|
0.13 units on a scale
Standard Deviation 0.34
|
|
Visual Analog Scales (VAS) - Drowsy - 230 Minutes
Placebo
|
0.11 units on a scale
Standard Deviation 0.43
|
0.17 units on a scale
Standard Deviation 0.58
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Depressed - Baseline
Thiopental
|
0.07 units on a scale
Standard Deviation 0.34
|
0.04 units on a scale
Standard Deviation 0.21
|
|
Visual Analog Scales (VAS) - Depressed - Baseline
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Depressed - 15 Minutes
Thiopental
|
0.02 units on a scale
Standard Deviation 0.15
|
0.13 units on a scale
Standard Deviation 0.63
|
|
Visual Analog Scales (VAS) - Depressed - 15 Minutes
Placebo
|
0.04 units on a scale
Standard Deviation 0.30
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Depressed - 45 Minutes
Thiopental
|
0.02 units on a scale
Standard Deviation 0.15
|
0.09 units on a scale
Standard Deviation 0.42
|
|
Visual Analog Scales (VAS) - Depressed - 45 Minutes
Placebo
|
0.04 units on a scale
Standard Deviation 0.30
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Depressed - 80 Minutes
Thiopental
|
0.02 units on a scale
Standard Deviation 0.15
|
0.04 units on a scale
Standard Deviation 0.21
|
|
Visual Analog Scales (VAS) - Depressed - 80 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Depressed - 110 Minutes
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Depressed - 110 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 170 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Depressed - 170 Minutes
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Depressed - 170 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 230 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Depressed - 230 Minutes
Thiopental
|
0.02 units on a scale
Standard Deviation 0.15
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Depressed - 230 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Anxious - Baseline
Thiopental
|
0.12 units on a scale
Standard Deviation 0.45
|
0.13 units on a scale
Standard Deviation 0.34
|
|
Visual Analog Scales (VAS) - Anxious - Baseline
Placebo
|
0.09 units on a scale
Standard Deviation 0.29
|
0.13 units on a scale
Standard Deviation 0.34
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Anxious - 15 Minutes
Thiopental
|
0.21 units on a scale
Standard Deviation 0.89
|
0.22 units on a scale
Standard Deviation 0.85
|
|
Visual Analog Scales (VAS) - Anxious - 15 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0.04 units on a scale
Standard Deviation 0.21
|
SECONDARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Anxious - 45 Minutes
Thiopental
|
0.07 units on a scale
Standard Deviation 0.34
|
0.13 units on a scale
Standard Deviation 0.46
|
|
Visual Analog Scales (VAS) - Anxious - 45 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Anxious - 80 Minutes
Thiopental
|
0.05 units on a scale
Standard Deviation 0.31
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Anxious - 80 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0.04 units on a scale
Standard Deviation 0.21
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Anxious - 110 Minutes
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Anxious - 110 Minutes
Placebo
|
0.02 units on a scale
Standard Deviation 0.15
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 170 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Anxious - 170 Minutes
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Visual Analog Scales (VAS) - Anxious - 170 Minutes
Placebo
|
0.04 units on a scale
Standard Deviation 0.30
|
0.04 units on a scale
Standard Deviation 0.21
|
SECONDARY outcome
Timeframe: 230 minutesPopulation: All available data was utilized in the analysis using mixed models.
visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Visual Analog Scales (VAS) - Anxious - 230 Minutes
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0.04 units on a scale
Standard Deviation 0.21
|
|
Visual Analog Scales (VAS) - Anxious - 230 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0.04 units on a scale
Standard Deviation 0.21
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline
Thiopental
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
|
Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes
Thiopental
|
2.57 units on a scale
Standard Deviation 3.35
|
1.74 units on a scale
Standard Deviation 1.79
|
|
Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes
Placebo
|
0.02 units on a scale
Standard Deviation 0.15
|
0.04 units on a scale
Standard Deviation 0.21
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes
Thiopental
|
0.73 units on a scale
Standard Deviation 1.58
|
0.83 units on a scale
Standard Deviation 1.56
|
|
Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes
Thiopental
|
0.43 units on a scale
Standard Deviation 1.59
|
0.22 units on a scale
Standard Deviation 0.42
|
|
Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline
Thiopental
|
0.02 units on a scale
Standard Deviation 0.15
|
0 units on a scale
Standard Deviation 0
|
|
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes
Thiopental
|
1.43 units on a scale
Standard Deviation 2.39
|
1.04 units on a scale
Standard Deviation 1.72
|
|
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes
Placebo
|
0.02 units on a scale
Standard Deviation 0.15
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: 80 minutesPopulation: All available data was utilized in the analysis using mixed models.
Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes
Thiopental
|
0.68 units on a scale
Standard Deviation 1.54
|
0.35 units on a scale
Standard Deviation 0.65
|
|
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0.09 units on a scale
Standard Deviation 0.42
|
SECONDARY outcome
Timeframe: 110 minutesPopulation: All available data was utilized in the analysis using mixed models.
Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes
Thiopental
|
0.21 units on a scale
Standard Deviation 0.67
|
0.17 units on a scale
Standard Deviation 0.49
|
|
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes
Placebo
|
0 units on a scale
Standard Deviation 0
|
0 units on a scale
Standard Deviation 0
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Pegboard Task - Baseline (Dominant Hand)
Thiopental
|
58.49 seconds
Standard Deviation 9.39
|
60.57 seconds
Standard Deviation 10.56
|
|
Pegboard Task - Baseline (Dominant Hand)
Placebo
|
57.37 seconds
Standard Deviation 6.84
|
60.78 seconds
Standard Deviation 7.59
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Pegboard Task - 15 Minutes (Dominant Hand)
Thiopental
|
84.56 seconds
Standard Deviation 22.92
|
82.04 seconds
Standard Deviation 16.36
|
|
Pegboard Task - 15 Minutes (Dominant Hand)
Placebo
|
65.11 seconds
Standard Deviation 10.04
|
69.61 seconds
Standard Deviation 13.68
|
SECONDARY outcome
Timeframe: BaselinePopulation: All available data was utilized in the analysis using mixed models.
The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds.
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Pegboard Task - Baseline (Non-Dominant Hand)
Thiopental
|
64.19 seconds
Standard Deviation 10.15
|
66.52 seconds
Standard Deviation 10.95
|
|
Pegboard Task - Baseline (Non-Dominant Hand)
Placebo
|
62.98 seconds
Standard Deviation 8.29
|
69.83 seconds
Standard Deviation 13.21
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds.
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Pegboard Task - 15 Minutes (Non-Dominant Hand)
Thiopental
|
91.19 seconds
Standard Deviation 23.23
|
87.09 seconds
Standard Deviation 19.99
|
|
Pegboard Task - 15 Minutes (Non-Dominant Hand)
Placebo
|
71.13 seconds
Standard Deviation 12.57
|
75.48 seconds
Standard Deviation 13.74
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function based on word recall. (0 = no words recalled - 36 = all words recalled)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Hopkins Verbal Learning Task (HVLT) - Total Recall
Thiopental
|
25.88 words recalled
Standard Deviation 6.14
|
26.96 words recalled
Standard Deviation 4.41
|
|
Hopkins Verbal Learning Task (HVLT) - Total Recall
Placebo
|
29.02 words recalled
Standard Deviation 3.94
|
29.35 words recalled
Standard Deviation 3.80
|
SECONDARY outcome
Timeframe: 45 minutesPopulation: All available data was utilized in the analysis using mixed models.
Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function with word recall at 30 minutes) (0 no words recalled - 12 all words recalled)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Hopkins Verbal Learning Task (HVLT) - Delayed Recall
Thiopental
|
8.29 words recalled
Standard Deviation 3.39
|
8.74 words recalled
Standard Deviation 3.24
|
|
Hopkins Verbal Learning Task (HVLT) - Delayed Recall
Placebo
|
10.44 words recalled
Standard Deviation 1.75
|
10.04 words recalled
Standard Deviation 2.08
|
SECONDARY outcome
Timeframe: 15 minutesPopulation: All available data was utilized in the analysis using mixed models.
Verbal Fluency Task: requires subjects to generate as many words as possible beginning with a single letter (e.g., "H") during a one-minute interval. (total words in one-minute interval)
Outcome measures
| Measure |
Family History Negative for Alcoholism
n=46 Participants
Family History Negative for Alcoholism subjects will receive 2 interventions
|
Family History Positive
n=23 Participants
Family History Positive for Alcoholism subjects will receive 2 interventions
|
|---|---|---|
|
Verbal Fluency
Thiopental
|
13.47 number of words
Standard Deviation 4.11
|
13.96 number of words
Standard Deviation 3.34
|
|
Verbal Fluency
Placebo
|
14.35 number of words
Standard Deviation 4.42
|
14.04 number of words
Standard Deviation 3.23
|
Adverse Events
Family History Negative for Alcoholism
Family History Positive for Alcoholism
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr. Ismene L. Petrakis, Professor of Psychiatry
Yale University School of Medicine
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place