Synergy Between Stent and Drugs to Avoid Ischemic Recurrences After Percutaneous Coronary Intervention

Summary

The duration of dual antiplatelet treatment (i.e. asprin and clopidogrel) after drug-eluting stent implantation is highly debated. This study will evaluate the value of extending such treatment up to 2 years after the procedure as compared to conventional treatment according to our national health institute guidelines (i.e. minimum 1 month after bare metal stent and 6 months after drug-eluting stent) on the composite endpoint of death, MI or stroke.

Conditions

• Coronary Artery Disease

Interventions

DRUG

clopidogrel treatment after bare metal stent implantation

extending use of clopidogrel on top of aspirin up to 24 months after coronary implantation of bare metal stent

DRUG

clopidogrel treatment after bare metal stent implantation

Adding clopidogrel on top of Aspirin according to the practice suggested by Italian national institute of health, i.e. 1 month after BMS implantation.

DRUG

clopidogrel after zotarolimus-eluting stent implantation

extending use of clopidogrel on top of aspirin up to 24 months after coronary implantation of zotarolimus-eluting stent coronary implantation

DRUG

clopidogrel after paclitaxel-eluting stent implantation

extending use of clopidogrel on top of aspirin up to 24 months after coronary implantation of paclitaxel-eluting stent

DRUG

clopidogrel after everolimus-eluting stent implantation

extending use of clopidogrel on top of aspirin up to 24 months after coronary implantation of Everolimus-eluting stent

DRUG

clopidogrel after zotarolimus-eluting stent implantation

Adding clopidogrel on top of Aspirin according to the practice suggested by Italian national institute of health, i.e. 6 month after DES implantation.

DRUG

clopidogrel after paclitaxel-eluting stent implantation

Adding clopidogrel on top of Aspirin according to the practice suggested by Italian national institute of health, i.e. 6 month after DES implantation.

DRUG

clopidogrel after everolimus-eluting stent implantation

Adding clopidogrel on top of Aspirin according to the practice suggested by Italian national institute of health, i.e. 6 month after DES implantation.

Sponsors & Collaborators

• Marco Valgimigli

  lead OTHER

Principal Investigators

• Marco Valgimigli, MD, PhD · University of Ferrara, Italy

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2006-12-31

Primary Completion

2010-12-31

Completion

2012-10-31

Countries

• Italy

Study Locations