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Vasopressin and V2 Receptor in Meniere's Disease

NCT00599560 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 135

Last updated 2016-03-29

No results posted yet for this study

Summary

Summary: Some of sicknesses are well known to be provoked by inadequate adaptation to physical and/or psychogenic stress in their daily life. Meniere's disease is also a common inner ear disease accompanied with vertigo, hearing loss and tinnitus especially in civilized people under stressed life style. Its oto-pathology was firstly revealed in 1938 to be inner ear endolymphatic hydrops through the temporal bone study. To elucidate the neuroscientific relationship between "stress" and "inner ear", we examined plasma vasopressin (the anti-diuretic "stress" hormone) and its receptor, V2R in the endolymphatic sac (the "inner ear" endo-organ for endolymph absorption) in Meniere's patients.

Conditions

  • Meniere Disease

Interventions

GENETIC

vasopressin, V2 receptor and cyclic AMP

plasma vasopressin, V2 receptor, cyclic AMP

Sponsors & Collaborators

  • Osaka City University

    collaborator OTHER

  • Osaka University

    lead OTHER

Principal Investigators

  • Tadashi Kitahara, M.D.,Ph.D. · Department of ORL, Osaka University, School of Medicine

  • Hiroshi Kiyama, Ph.D. · Department of Neuroanatomy, Osaka City University, School of Medicine

  • Takeshi Kubo, M.D.,Ph.D. · Department of ORL, Osaka University, School of Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1998-04-30
Primary Completion
2005-09-30
Completion
2005-09-30

Countries

  • Japan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00599560 on ClinicalTrials.gov