Evaluating the Presence of Blood Clots in People With Heparin-Induced Thrombocytopenia (HIT) (The HOT Study)

Summary

Heparin-induced thrombocytopenia (HIT), a condition characterized by low platelet levels and possible blood clots, occurs in a small number of people after treatment with the drug heparin. Some people with HIT may show symptoms of a blood clot at the time of HIT diagnosis, but in another form of HIT, known as isolated HIT, people do not show blood clot symptoms even though they might have a blood clot. This study will use ultrasound tests to evaluate the presence of blood clots at the time of an HIT diagnosis and in the following month.

Conditions

• Thrombocytopenia

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Carelon Research

  lead OTHER

Principal Investigators

• Susan F. Assmann, PhD · Carelon Research

• Eliot C. Williams, MD, PhD · University of Wisconsin, Madison

• Kenneth D. Friedman, MD · Froedtert Hospital

• David Kress, MD · St. Luke's Medical Center

• Ronald Go, MD · Gunderson Clinic

• Keith McCrae, MD · Case Western Reserve University

• Ellis Neufeld, MD · Boston Children's Hospital

• Jeff Zwicker, MD · Beth Israel Deaconess Medical Center

• Judith Lin, MD · Brigham and Women's Hospital

• Thomas Ortel, MD, PhD · Duke University

• Cassandra Josephson, MD · Emory University

• Jodi Segal, MD, MPH · Johns Hopkins University

• David Kuter, MD · Massachusetts General Hospital

• Terry Gernsheimer, MD · University of Washington

• Cindy Leissinger, MD · Tulane University

• Thomas Raife, MD · University of Iowa

• Ann Zimrin, MD · University of Maryland

• Jeffrey McCullough, MD · University of Minnesota

• Nigel Key, MB, MRCP · University of North Carolina

• Ravindra Sarode, MD · University of Texas Southwestern Medical Center

• Barbara Konkle, MD · University of Pennsylvania

• Joseph Kiss, MD · University of Pittsburgh

Eligibility

Min Age

6 Months

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2008-01-31

Primary Completion

2008-09-30

Completion

2008-09-30

Countries

• United States

Study Locations