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Effect of Lubiprostone on Nutritional Status and Pulmonary Function in Adults With Cystic Fibrosis

NCT00577499 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 7

Last updated 2015-03-04

No results posted yet for this study

Summary

Cystic fibrosis (CF) results in thickened secretions in multiple organ systems including the lungs and gastrointestinal (GI) tract. Patients commonly suffer from nutritional deficiency, and achieving and maintaining adequate nutrition is an important goal of therapy because it is positively correlated with lung function. Lubiprostone activates chloride channels in the GI tract. Because its mechanism of action closely parallels the disease pathology, lubiprostone has the potential to provide GI benefits beyond the relief of constipation. This project is an observational study to examine the effects of lubiprostone on nutritional status and lung function in adults with CF. Our hypothesis is that lubiprostone will have beneficial effects on nutritional status.

Conditions

Sponsors & Collaborators

  • American Society of Health-System Pharmacists Research and Education Foundation

    collaborator OTHER

  • University of Arkansas

    lead OTHER

Principal Investigators

  • Catherine O'Brien, PharmD · University of Arkansas

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-10-31
Primary Completion
2009-06-30
Completion
2009-06-30

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00577499 on ClinicalTrials.gov