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Registry for Vascular Anomalies Associated With Coagulopathy

NCT00576888 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2019-09-16

No results posted yet for this study

Summary

PURPOSE The purpose of this study is to learn more about multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT). MLT is a rare vascular disorder characterized by multiple congenital skin and visceral lesions, profound thrombocytopenia, and gastrointestinal bleeding. The skin lesions may appear red, brown or blue, often misdiagnosed as hemangiomas. The gastrointestinal tract, liver, and lungs are the most common internal organs involved. The severe thrombocytopenia (low platelets) is believed to be the result of platelet trapping within the skin and visceral vascular lesions. Severe and chronic gastrointestinal bleeding is common during infancy and early childhood. Although a relatively newly described entity, MLT was likely previously reported as hemangiomas, blue rubber bleb nevus syndrome, diffuse hemangiomatosis, Kasabach-Merritt phenomenon, and hereditary hemorrhagic telangiectasia. The term cutaneovisceral angiomatosis with thrombocytopenia is also a term used for this same disease. This study is a longitudinal cohort study of MLT to collect detailed clinical data on the distribution of disease, disease severity, and complications. This data will be used to create diagnostic criteria and an evaluation protocol for infants with this disease

Conditions

  • Multifocal Lymphangioendotheliomatosis With Thrombocytopenia
  • Cutaneovisceral Angiomatosis With Thrombocytopenia
  • Vascular Anomaly With Thrombocytopenia
  • Hemangiomas

Interventions

OTHER

no intervention

no intervention - observational only

Sponsors & Collaborators

  • Medical College of Wisconsin

    lead OTHER

Principal Investigators

  • Beth Drolet, MD · Medical College of Wisconsin

  • Ulrich Broeckel, MD · Medical College of Wisconsin

  • Howard Jacob, PhD · Medical College of Wisconsin

  • Michael Kelly, MD, PhD · Medical College of Wisconsin

  • Richard Noel, MD, PhD · Medical College of Wisconsin

  • Paula North, MD, PhD · Medical College of Wisconsin

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-11-30
Primary Completion
2018-12-31
Completion
2019-04-05

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00576888 on ClinicalTrials.gov