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The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder

NCT00571246 · Status: WITHDRAWN · Phase: PHASE3 · Type: INTERVENTIONAL

Last updated 2020-11-16

No results posted yet for this study

Summary

The objective of this study is to evaluate the efficacy of topiramate (250mg) or lamotrigine (250mg) versus placebo in reducing alcohol consumption and decreasing symptoms of PTSD in patients with comorbid AD and PTSD.

Conditions

  • Alcohol Dependence
  • Post Traumatic Stress Disorder

Interventions

DRUG

Topiramate

Participants are randomized to take Topiramate (250mg/day) 2 times a day

DRUG

lamotrigine

Participants are randomized to take Lamotrigine (250 mg/day) 2 times a day

OTHER

Placebo

Participants are randomized to take placebo

Sponsors & Collaborators

  • Yale University

    lead OTHER

Principal Investigators

  • Ismene L Petrakis, MD · VA Connecticut Healthcare System

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
FACTORIAL

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-06-30
Primary Completion
2016-06-30
Completion
2016-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00571246 on ClinicalTrials.gov