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Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus

NCT00568711 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 476

Last updated 2019-02-08

No results posted yet for this study

Summary

New antibiotics are required to have not only the antibacterial activity against doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any cross-resistance to others.

In this prospective, open-label, randomized trial, we enroll patients with mild-to-moderate scrub typhus. We compared the efficacy and safety of a 5-day rifampin therapy with those of a 5-day doxycycline therapy at Chosun University Hospital, or one of its two community-based affiliated hospitals which are all located in southwestern Korea between 2006 and 2009.

Conditions

  • Scrub Typhus

Interventions

DRUG

doxycycline

a 5-day course of 100 mg bid doses of doxycycline

DRUG

rifampin

a 5-day course of daily 600-mg doses of rifampin

Sponsors & Collaborators

  • Dong-Min Kim

    lead OTHER

Principal Investigators

  • Namsoo Cho · Director of Chosun University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-09-30
Primary Completion
2009-12-31
Completion
2009-12-31

Countries

  • South Korea

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00568711 on ClinicalTrials.gov