Evaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron Overload
NCT00564941 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 309
Last updated 2017-02-24
Summary
This study will evaluate the safety and efficacy of deferasirox in transfusion dependent Myelodysplastic Syndrome, Beta-thalassaemia major patients with chronic iron overload
Conditions
Interventions
- DRUG
-
deferasirox
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Novartis Pharmaceuticals · Novartis Pharmaceuticals
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2007-12-31
- Primary Completion
- 2011-07-31
- Completion
- 2011-07-31
Countries
- Hungary
Study Locations
More Related Trials
-
Safety and Efficacy of Deferasirox in Patients With Transfusion Dependent Iron Overload - a Non-comparative Extension Study
NCT01033747 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
A Study Assessing the Efficacy and Safety of Deferasirox in Patients With Transfusion-dependent Iron Overload
NCT00171821 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open-label Extension Study
NCT00873041 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of Deferasirox on Patients With Cardiac MRI T2* < 20 Msec
NCT00879242 ·Status: COMPLETED ·Phase: PHASE2
-
An Extension Study of Iron Chelation Therapy With Deferasirox (ICL670) in β-thalassemia Patients With Transfusional Iron Overload
NCT00171210 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Safety Study of Deferasirox in Patients With Non-transfusion Dependent Thalassemia
NCT01709838 ·Status: COMPLETED ·Phase: PHASE4
-
Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration)
NCT00171301 ·Status: COMPLETED ·Phase: PHASE4
-
Safety and Efficacy of Deferasirox in Combination With Desferoxamine in β-thalassaemia Patients With Severe Cardiac Iron Overload
NCT01459718 ·Status: TERMINATED ·Phase: PHASE2
-
Post Hematopoietic Stem Cell Transplantation
NCT01610297 ·Status: COMPLETED ·Phase: PHASE4
-
Deferasirox BID (Twice a Day) in Transfusion Dependent Thalassemia Patients With Inadequate Response to High Doses
NCT01948817 ·Status: WITHDRAWN ·Phase: PHASE2
-
Study of Deferasirox for Treatment of Transfusional Iron Overload in Myelodysplastic Patients
NCT00110266 ·Status: COMPLETED ·Phase: PHASE2
-
Extension Study of Iron Chelation Therapy With Deferasirox in Patients With Transfusional Iron Overload
NCT00379483 ·Status: COMPLETED ·Phase: PHASE2
-
Extension Study of Iron Chelation Therapy With Deferasirox in β-thalassemia and Rare Chronic Anemia Patients
NCT00303329 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients
NCT00110617 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload
NCT00600938 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of Oral Deferasirox (20 mg/kg/d) in Pts 3 to 6 Months After Allogeneic Hematopoietic Cell Transplantation Who Present With Iron Overload
NCT00654589 ·Status: COMPLETED ·Phase: PHASE4
-
Study for the Treatment of Transfusional Iron Overload in Myelodysplastic Patients
NCT00117507 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety of Deferasirox in Combination With Deferoxamine Followed by Deferasirox Monotherapy in Severe Cardiac Iron Overload
NCT01254227 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy of Deferasirox (ICL670) in Patients With Iron Overload Resulting From Hereditary Hemochromatosis
NCT00395629 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Open-label, Multicenter Study Assessing Preference for Deferasirox Film-coated Tablet Compared to Dispersible Tablet
NCT02993224 ·Status: COMPLETED ·Phase: PHASE2
-
Retrospective Evaluation of Adult and Pediatric Transfusion-dependent Patients Treated With Deferasirox Therapy
NCT01874405 ·Status: COMPLETED
-
Study to Evaluate Treatment Compliance, Efficacy and Safety of an Improved Deferasirox Formulation (Granules) in Pediatric Patients (2-<18 Years Old) With Iron Overload
NCT02435212 ·Status: COMPLETED ·Phase: PHASE2
-
An Open Label Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Efficacy of Deferasirox Administered to Chinese Patients With β-thalassemia Major Aged From 2 to Less Than 6 Years Old
NCT01724138 ·Status: WITHDRAWN ·Phase: PHASE4
-
Phase II Study to Investigate the Benefits of an Improved Deferasirox Formulation (Film-coated Tablet)
NCT02125877 ·Status: COMPLETED ·Phase: PHASE2
-
Deferasirox in Treating Patients With Very Low, Low, or Intermediate-Risk Red Blood Cell Transfusion Dependent Anemia or Myelodysplastic Syndrome
NCT02943668 ·Status: TERMINATED ·Phase: PHASE2