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Effect of Creatine and L-Arginine on Endothelial Function

NCT00551434 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 119

Last updated 2007-10-31

No results posted yet for this study

Summary

The study is a double blind 2x2 factorial study. Patients with coronary disease will be randomly be assigned to L-arginine (9 g/day), creatine 21 g/d, both, or neither dietary supplement. The function of the endothelium will be tested using ultrasound before and after each treatment. These studies will help us understand why the endothelium is abnormal in patients with coronary artery disease and how L-arginine is acting on endothelial function.

Conditions

Interventions

DIETARY_SUPPLEMENT

Creatine

Creatine 21 g daily

DIETARY_SUPPLEMENT

L-arginine and creatine

L-arginine

DIETARY_SUPPLEMENT

l-arginine

l-arginine 9 g daily

DIETARY_SUPPLEMENT

placebo, double

placebo

Sponsors & Collaborators

  • Boston University

    lead OTHER

Principal Investigators

  • Joseph A Vita, MD · Boston Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-08-31
Completion
2005-12-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00551434 on ClinicalTrials.gov