Asthma Clinical Research Network (ACRN) Trial - Best Adjustment Strategy for Asthma in Long Term (BASALT)

Summary

Asthma can be effectively controlled using inhaled corticosteroid medication. Treatment with inhaled corticosteroids often requires periodic adjustments to medication dosing and frequency levels. This study examines whether it is more beneficial to adjust corticosteroid treatment based on asthma symptoms and/or biomarkers of lung function versus standard medical guidelines.

Conditions

• Asthma

Interventions

BEHAVIORAL

Symptom-based adjustment

Symptom-based adjustment of beclomethasone dipropionate administered via a hydrofluoroalkane (HFA) inhaler (QVAR® 40 mcg or QVAR® 80 mcg)

BEHAVIORAL

Biomarker-based adjustment

Biomarker-based adjustment of beclomethasone dipropionate administered via a hydrofluoroalkane (HFA) inhaler (QVAR® 40 mcg or QVAR® 80 mcg)

BEHAVIORAL

Guideline-based adjustment

Guideline-based adjustment of beclomethasone dipropionate administered via a hydrofluoroalkane (HFA) inhaler (QVAR® 40 mcg or QVAR® 80 mcg)

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Milton S. Hershey Medical Center

  lead OTHER

Principal Investigators

• William J. Calhoun, MD · University of Texas, Galveston

• Mario Castro, MD · Washington University School of Medicine

• Robert F. Lemanske, MD · University of Wisconsin, Madison

• Richard J. Martin, MD · National Jewish Health

• Elliot Israel, MD · Brigham and Women's Hospital

• Stephen P. Peters, MD, PhD · Wake Forest University Health Sciences

• Homer A. Boushey, MD · University of California, San Francsico

• Stephen I. Wasserman, MD · University of California, San Diego

• Emily DiMango, MD · Columbia University

• Monica Kraft, MD · Duke University

• Reuben M. Cherniack, MD · National Jewish Health

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2007-06-30

Primary Completion

2010-07-31

Completion

2010-07-31

Countries

• United States

Study Locations